ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Simultaneous Detection of Neural Activity and Temperature in Photothermal Neural Stimulation.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A novel strategy for the photothermal treatment and electroencephalogram monitoring ofRSC advances · 2026Article
- Blood-catalyzed n-doped polymers for reversible optical neural control.Science (New York, N.Y.) · 2026Article
- Bio-Inspired Spike-Timing-Dependent Plasticity Learning with Metal Halide Perovskites: Toward Artificial Synaptic Functionality.ACS applied materials & interfaces · 2026Article
- Enhanced Neuromodulation Using PC-CNTs and NIR Photothermal Therapy for Preventing Ventricular Arrhythmias.International journal of nanomedicine · 2026Article
- A Sensitive Ratiometric Thermometer Constructed by AIEgen-Based Mixed Lanthanide MOF for Intracellular Temperature Mapping.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Simultaneous Detection of Neural Activity and Temperature in Photothermal Neural Stimulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
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Authors and funding
9 authors.
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Abstract
Photothermal neuromodulation is a promising non-electrical neural stimulation technology for treating brain diseases through optically induced cell membrane temperature changes. However, the technology faces limitations in understanding its mechanism and impact on cellular behavior due to the restriction of directly measuring temperature changes at the cell interface from a very close distance during optical stimulation of neural cells, necessitating advancements in high-precision temperature sensing and electrical recording without light interference. This challenge is addressed by developing ultrasensitive cell membrane interface temperature sensors integrated with low-noise electrical recording capabilities. Transparent resistive temperature detectors, composed of a 10 nm thickness of ultrathin Au film fabricated by polyelectrolyte seed layer-induced thermal evaporation, achieved precise measurement and control of temperature changes without significant light interference and self-heating. A transparent electrode composed of the same ultrathin Au layer shows low-noise electrical recordings of neural signals upon photothermal stimulation. Using this multifunctional system, it is demonstrated that an average increase of 2.34 °C at neuronal cell surfaces results in over 95% suppression of hippocampal neural spike activities. The approach provides unprecedented insights into the mechanisms of photothermal neuromodulation and its effects on cellular behavior, paving the way for advanced treatments of neurological disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.