Evidence map›Paper›PMID 40135890›Full record

ArticleJournal of virology2025

ZYG11B suppresses multiple enteroviruses by triggering viral VP1 degradation.

Li Tian, Zhizhong Mi, Weijing Yang, Jing Chen, Xiulong Wei, Wenyan Zhang, Zhaolong Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Li Tian *Institute of Virology and AIDS Research, the First Hospital of Jilin University, Changchun, Jilin, China.
Zhizhong Mi *Institute of Virology and AIDS Research, the First Hospital of Jilin University, Changchun, Jilin, China.
Weijing YangInstitute of Virology and AIDS Research, the First Hospital of Jilin University, Changchun, Jilin, China.
Jing ChenInstitute of Virology and AIDS Research, the First Hospital of Jilin University, Changchun, Jilin, China.
Xiulong WeiInstitute of Virology and AIDS Research, the First Hospital of Jilin University, Changchun, Jilin, China.
Wenyan ZhangInstitute of Virology and AIDS Research, the First Hospital of Jilin University, Changchun, Jilin, China.ORCID 0000-0003-4507-521X
Zhaolong LiInstitute of Virology and AIDS Research, the First Hospital of Jilin University, Changchun, Jilin, China.ORCID 0000-0003-3795-7220

Funding

Jilin University 2023B03Key Laboratory of Molecular Virology, Jilin Province 20102209National Key Research and Development Program of China 2021YFC2301900 and 2301904,2023YFC2306603National Natural Science Foundation of China 82341062,82472251National Natural Science Foundation of China 82341072,81930062,82272316Science and Technology Department of Jilin Province YDZJ202201ZYTS587Science and Technology Department of Jiln Province YDZJ202301ZYTS521
6 · The paper itself

Abstract

Enterovirus 71 (EV71) is a major cause of hand, foot, and mouth disease, particularly affecting pediatric populations worldwide. The role of ZYG11B, a CUL2-complex-associated E3 ubiquitin ligase from the Zyg-11 family, in antiviral defense against EV71 remains unclear. To our knowledge, this study is the first to reveal that ZYG11B targets EV71 VP1 for proteasomal degradation via the ubiquitin-proteasome pathway, with CRL2 IMPORTANCE: E3 ubiquitin ligases and deubiquitinases have become important topics of competition between viruses and hosts. Here, we identified CRL2

Indexed as

Capsid ProteinsEnterovirusEnterovirus A, HumanEnterovirus InfectionsUbiquitin-Protein LigasesCullin ProteinsHEK293 CellsHeLa CellsHost-Pathogen InteractionsHumansProteasome Endopeptidase ComplexProtein BindingProteolysisUbiquitinationCapsid ProteinsCullin ProteinsProteasome Endopeptidase ComplexUbiquitin-Protein LigasesCRL2enterovirusEV71ubiquitinationZYG11B

Identifiers

PMID40135890
PMCPMC11998487

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.