Evidence map›Paper›PMID 40135873›Full record

ArticlemBio2025

Discovery of novel antifungal drugs via screening repurposing libraries against

Sarah Saeger, Kathryn West-Jeppson, Yu-Rou Liao, Althea Campuzano, Jieh-Juen Yu, Jose Lopez-Ribot, Chiung-Yu Hung

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Drug Discovery and Repurposing forJournal of fungi (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sarah SaegerDepartment of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA.ORCID 0000-0003-4959-3321
Kathryn West-JeppsonDepartment of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA.
Yu-Rou LiaoDepartment of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA.
Althea CampuzanoDepartment of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA.
Jieh-Juen YuDepartment of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA.
Jose Lopez-RibotDepartment of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA.ORCID 0000-0003-1992-3270
Chiung-Yu HungDepartment of Molecular Microbiology and Immunology, South Texas Center for Emerging Infectious Diseases, The University of Texas at San Antonio, San Antonio, Texas, USA.ORCID 0000-0003-1091-3420

Funding

Screening Repurposing Libraries for the Identification of Drugs with Novel anti-Coccidioidal ActivityU19AI166761 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI CHIUNG-YU HUNG · 2022 to 2026
$8.1M
Development of a multivalent vaccine against Coccidioides infectionR01AI135005 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI HUNG, CHIUNG-YU · 2018 to 2022
$1.9M
Apply an imaging flow cytometry method to screen chemical libraries for identifying and repurposing novel drugs against coccidioidomycosisR21AI149015 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI HUNG, CHIUNG-YU · 2020 to 2021
$403k
Repurposing Drugs to Discover Novel Antifungals for CoccidioidomycosisF31AI186506 · NIAID · UNIVERSITY OF TEXAS SAN ANTONIO · PI SAEGER, SARAH BETH · 2024 to 2024
$38k
National Institute of Allergy and Infectious Diseases R21-AI149015NIAID NIH HHS F31 AI186506NIAID NIH HHS R01 AI135005NIAID NIH HHS R21 AI149015NIAID NIH HHS U19 AI166761
6 · The paper itself

Abstract

Coccidioidomycosis or valley fever is a treatment-limited fungal infection endemic to the alkaline deserts of North and South America for which two classes of antifungals are typically used: the polyenes and the triazoles. In light of the limited usefulness of the echinocandins and a growing trend of azole resistance, it is essential that we identify novel antifungals. In this study, we have developed and optimized a screening methodology for identifying potential antifungals effective against

Indexed as

Antifungal AgentsCoccidioidesDrug RepositioningCoccidioidomycosisDrug DiscoveryDrug Evaluation, PreclinicalHumansMicrobial Sensitivity TestsSmall Molecule LibrariesAntifungal AgentsSmall Molecule Librariesantifungal drug discoveryassay developmentCoccidioidescoccidioidomycosisdrug repurposinghigh-throughput screeningspherulesvalley fever

Identifiers

PMID40135873
PMCPMC12077158

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.