Evidence map›Paper›PMID 40135785›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Achieving High-Performance Transcranial Ultrasound Transmission Through Mie and Fano Resonance in Flexible Metamaterials.

Jie Chen, Bing Liu, Genshen Peng, Linming Zhou, Chengwei Tan, Jiale Qin, Juan Li, Zijian Hong, Yongjun Wu, Minghui Lu and 2 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jie ChenSchool of Materials Science and Engineering, Institute of Fundamental and Transdisciplinary Research, State Key Laboratory of Silicon and Advanced Semiconductor Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou, Zhejiang, 310030, China.
Bing LiuCollege of Electronic Information and Engineering, Hangzhou Dianzi University, Hangzhou, Zhejiang, 310018, China.
Genshen PengSchool of Materials Science and Engineering, Institute of Fundamental and Transdisciplinary Research, State Key Laboratory of Silicon and Advanced Semiconductor Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou, Zhejiang, 310030, China.
Linming ZhouSchool of Materials Science and Engineering, Institute of Fundamental and Transdisciplinary Research, State Key Laboratory of Silicon and Advanced Semiconductor Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou, Zhejiang, 310030, China.
Chengwei TanDepartment of Ultrasound, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Jiale QinDepartment of Ultrasound, Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310006, China.
Juan LiZhejiang University of Technology, College of Materials Science and Engineering, Hangzhou, 310014, China.
Zijian HongSchool of Materials Science and Engineering, Institute of Fundamental and Transdisciplinary Research, State Key Laboratory of Silicon and Advanced Semiconductor Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou, Zhejiang, 310030, China.
Yongjun WuSchool of Materials Science and Engineering, Institute of Fundamental and Transdisciplinary Research, State Key Laboratory of Silicon and Advanced Semiconductor Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou, Zhejiang, 310030, China.
Minghui LuNational Laboratory of Solid State Microstructures and Department of Materials Science and Engineering, Nanjing University, Nanjing, Jiangsu, 210093, China.
Feiyan CaiPaul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Yuhui HuangSchool of Materials Science and Engineering, Institute of Fundamental and Transdisciplinary Research, State Key Laboratory of Silicon and Advanced Semiconductor Materials, Cyrus Tang Center for Sensor Materials and Applications, Zhejiang University, Hangzhou, Zhejiang, 310030, China.ORCID https://orcid.org/0000-0001-7493-0487

Funding

Fundamental Research Funds for the Central Universities 226-2024-00120National Key R&D Program of China 2021YFB3801802National Key R&D Program of China 2022YFB3204300Special Support Plan for High Level Talents in Zhejiang Province 2023R5231
6 · The paper itself

Abstract

Transcranial ultrasound holds great potential in medical applications. However, the effective transmission of ultrasound through the skull remains challenging due to the acoustic impedance mismatch, as well as the non-uniform thickness, and the curved surface. To overcome these challenges, this work introduces an innovative Mie-resonance flexible metamaterial (MRFM), which consists of periodically arranged low-speed micropillars embedded within a high-speed flexible substrate. The MRFM generates Mie-resonance, which couples with the skull to form Fano resonance, thereby enhancing ultrasound transmittance through the skull. Simulation results demonstrate that the proposed resonance solution significantly increases transcranial ultrasound transmittance from 33.7% to 75.2% at 0.309 MHz. For the fabrication of the MRFM, porous nickel foam is used as the Mie micropillars, and agarose hydrogel serves as the flexible substrate. Experimental results demonstrate enhanced ultrasound transmittance from 20.6% to 73.3% at 0.33 MHz with the MRFM, which shows good agreement with the simulation results, further validating the effectiveness of the design. The simplicity, tunability, and flexibility of the MRFM represent a significant breakthrough, addressing the limitations of conventional rigid metamaterials. This work lays a solid theoretical and experimental foundation for advancing the clinical application of transcranial ultrasound stimulation and neuromodulation.

Indexed as

SkullHumansfano resonanceflexible metamaterialsmie resonancetranscranial ultrasound

Identifiers

PMID40135785
PMCPMC12097009

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.