Evidence map›Paper›PMID 40135732›Full record

ArticleeLife2025

Reported transgenerational responses to

Daniel Patrick Gainey, Andrey V Shubin, Craig P Hunter

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Daniel Patrick GaineyDepartment of Molecular and Cellular Biology, Harvard University, Divinity Avenue, The Biological Laboratory, Cambridge, United States.ORCID https://orcid.org/0000-0002-0000-7187
Andrey V ShubinDepartment of Molecular and Cellular Biology, Harvard University, Divinity Avenue, The Biological Laboratory, Cambridge, United States.
Craig P HunterDepartment of Molecular and Cellular Biology, Harvard University, Divinity Avenue, The Biological Laboratory, Cambridge, United States.ORCID https://orcid.org/0000-0002-1456-5657

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5M
Molecular Genetic Analysis of Extracellular RNAs in C. ElegansR01GM089795 · NIGMS · HARVARD UNIVERSITY · PI HUNTER, CRAIG PATRICK · 2009 to 2021
$4.6M
John Templeton Foundation 62579NIGMS NIH HHS R01 GM089795NIH HHS GM089795NIH HHS P40 OD010440
6 · The paper itself

Abstract

We report our attempt to replicate reports of transgenerational epigenetic inheritance in

Indexed as

Caenorhabditis elegansEpigenesis, GeneticPseudomonas aeruginosaAnimalsCaenorhabditis elegans ProteinsInheritance PatternsTransforming Growth Factor betaCaenorhabditis elegans ProteinsDAF-7 protein, C elegansTransforming Growth Factor betaC. elegansgeneticsgenomicsintergenerational inheritancesid-1sid-2transgenerational

Identifiers

PMID40135732
PMCPMC11942167

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.