ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2025
Treatment of sleep-disordered breathing in opioid users with adaptive servo-ventilation: a subgroup analysis of the European READ-ASV registry.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03032029 (Registry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-Ventilation), which is not on this map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Registry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-Ventilation
Who cites it
3 citing papers in PubMed.
- Prevalence and management of residual respiratory events in OSA patients treated with CPAP: a prospective observational clinical experience.Sleep & breathing = Schlaf & Atmung · 2026Observational
- When invalid data becomes the dominant evidence in ChatGPT.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- ERS Congress 2025: highlights from the Sleep Disordered Breathing Assembly.ERJ open research · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesCentral sleep-disordered breathing (SDB) is associated with negative health outcomes. Intake of opioids influences stability of breathing and can cause central apneas. Screening for and treatment of SDB is recommended for individuals who use opioids. This subanalysis of the READ-ASV (Registry on the Treatment of Central and Complex Sleep-Disordered Breathing with Adaptive Servo-Ventilation) investigated the effects of adaptive servo-ventilation therapy (ASV) on SDB symptoms in people using opioids.
methodsPatients initiated on ASV who reported intake of opioids at baseline were included in this analysis of real-world registry data. Patients were prospectively followed-up for 12 months. Disease-specific quality of life was assessed with the Functional Outcomes of Sleep Questionnaire. Sleepiness was measured with the Epworth Sleepiness Scale. Symptomatic patients were defined as having a Functional Outcomes of Sleep Questionnaire score of < 17.9 and an Epworth Sleepiness Scale score of > 10.
resultsEighty-six patients who reported opioid use were included. The population had severe SDB (median apnea-hypopnea index: 55 events/h), the majority (n = 75 [87%]) had comorbidities, and 81.6% (40/49 with follow-up available questionnaires) were symptomatic at baseline. ASV effectively treated SDB (residual median apnea-hypopnea index from device data [apnea-hypopnea index flow]: 1.5 events/h). The Functional Outcomes of Sleep Questionnaire (+1.4 points;
conclusionsASV treatment of central breathing disorders in individuals using opioids resolved SDB and was associated with significant improvements in disease-specific quality of life and sleepiness. ASV treatment may therefore be an actionable intervention to counteract the negative effects of opioids on SDB and quality of life. CLINICAL
trial registrationRegistry: ClinicalTrials.gov; Name: Registry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-Ventilation (READ-ASV); URL: https://www.clinicaltrials.gov/study/NCT03032029; Identifier: NCT03032029. CITATION: Pepin J-L, Benjafield AV, Munt O, Woehrle H, Heinzer R, Arzt M; for the READ-ASV Investigators. Treatment of sleep-disordered breathing in opioid users with adaptive servo-ventilation: a subgroup analysis of the European READ-ASV registry.
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