Evidence map›Paper›PMID 40135570›Full record

ArticleCNS neuroscience & therapeutics2025

Differences Between Patients With Multiple System Atrophy With Predominant Parkinsonism and Parkinson's Disease Based on fNIRS and Gait Analysis.

Mengxi Gao, Heng Zhang, Aidi Shan, Yongsheng Yuan, Xingyue Cao, Lina Wang, Caiting Gan, Huimin Sun, Shiyi Ye, Chenghui Wan and 2 more

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Article in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Mengxi GaoDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID 0009-0000-8303-9020
Heng ZhangDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID 0000-0002-9527-0075
Aidi ShanDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Yongsheng YuanDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Xingyue CaoDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Lina WangDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Caiting GanDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Huimin SunDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Shiyi YeDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Chenghui WanDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Youyong KongJiangsu Provincial Joint International Research Laboratory of Medical Information Processing, School of Computer Science and Engineering, Southeast University, Nanjing, China.
Kezhong ZhangDepartment of Neurology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.ORCID 0000-0002-4437-1095

Funding

National Natural Science Foundation of China 81671258National Natural Science Foundation of China 81901297
6 · The paper itself

Abstract

objectiveTo investigate the differences in gait parameters and cortical activity during a single-task walking (STW) and cognitive dual-task walking (DTW) between multiple system atrophy with predominant parkinsonism (MSA-P) and Parkinson's disease (PD).

methods24 MSA-P patients, 20 PD patients, and 22 healthy controls (HCs) were enrolled. Gait parameters were collected using a portable inertial measurement unit system, and the relative change of oxyhemoglobin (ΔHbO

resultsMSA-P patients had increased step length variability and higher ΔHbO

conclusionMSA-P patients demonstrate more severe gait disturbance and increased DLPFC activity compared with PD patients and HCs. Gait parameters and cortical activity could be a potential features discerning MSA-P patients and PD patients.

Indexed as

Gait AnalysisMultiple System AtrophyParkinson DiseaseParkinsonian DisordersAgedFemaleHumansMaleMiddle AgedOxyhemoglobinsSpectroscopy, Near-InfraredOxyhemoglobinsdorsolateral prefrontal cortexfunctional near‐infrared spectroscopygait impairmentsmultiple system atrophy with predominant parkinsonismParkinson's disease

Identifiers

PMID40135570
PMCPMC11937913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.