Evidence map›Paper›PMID 40135428›Full record

ArticleJournal of materials chemistry. B2025

Breast cancer extracellular matrix invasion depends on local mechanical loading of the collagen network.

Hanadi M Alqosiri, Hadeel M Alqasiri, Sara E Alqasire, Victor E Nava, Bidhan C Bandyopadhyay, Christopher B Raub

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of materials chemistry. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hanadi M AlqosiriDepartment of Biomedical Engineering, School of Engineering, Catholic University of America, Washington, DC, 20064, USA. raubc@cua.edu.
Hadeel M AlqasiriDepartment of Biomedical Engineering, School of Engineering, Catholic University of America, Washington, DC, 20064, USA. raubc@cua.edu.
Sara E AlqasireDepartment of Biomedical Engineering, School of Engineering, Catholic University of America, Washington, DC, 20064, USA. raubc@cua.edu.
Victor E NavaVeterans Affairs Medical Center, Washington, DC, 20422, USA.
Bidhan C BandyopadhyayDepartment of Biomedical Engineering, School of Engineering, Catholic University of America, Washington, DC, 20064, USA. raubc@cua.edu.
Christopher B RaubDepartment of Biomedical Engineering, School of Engineering, Catholic University of America, Washington, DC, 20064, USA. raubc@cua.edu.ORCID http://orcid.org/0000-0001-9487-0979

Funding

A dual-modality quantitative phase and polarized light microscope to assess cell motility and extracellular matrix remodeling during invasionR03EB028017 · NIBIB · CATHOLIC UNIVERSITY OF AMERICA · PI RAUB, CHRISTOPHER B · 2019 to 2020
$159k
BLRD VA I21 BX006418NIBIB NIH HHS R03 EB028017
6 · The paper itself

Abstract

Active mechanical stresses in and around tumors affect cancer cell behavior and independently regulate cancer progression. To investigate the role of mechanical stress in breast cancer cell invasion, magnetic alginate beads loaded with iron oxide nanoparticles were coated with MDA-MB-231 breast cancer cells and embedded in a three-dimensional extracellular matrix (ECM) model subjected to an external magnetic field during culture. Bead displacement, cell shape and patterns of invasion of the collagen gel, and cell proliferation were assessed over 7 days of culture. The alginate beads swelled over the first 24 h in culture, creating circumferential stress akin to that created by tumor growth, while bead magnetic properties enabled local mechanical loading (compression, tension, and relaxation) and motion within the

Indexed as

Breast NeoplasmsCollagenExtracellular MatrixAlginatesCell Line, TumorCell ProliferationFemaleHumansStress, MechanicalAlginatesCollagen

Identifiers

PMID40135428
PMCPMC12245604

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.