Evidence map›Paper›PMID 40135426›Full record

ArticleDrug and alcohol review2025

Changing patterns of opioid agonist therapy prescribing in a network of specialised clinics providing care to people with opioid use disorder in Victoria, Australia, 2015 to 2023.

Joshua Dawe, Anna Lee Wilkinson, Michael Curtis, Jason Asselin, Charles Henderson, Eric Makoni, Paul Dietze, Margaret Hellard, Mark Stoové, Australian Collaboration for Coordinated Enhanced Sentinel Surveillance of Blood Borne Viruses and Sexually Transmissible Infections (ACCESS)

Abstract read
In one paragraph

Article in Drug and alcohol review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Joshua DaweDisease Elimination, Burnet Institute, Melbourne, Australia.ORCID 0000-0002-3227-9849
Anna Lee WilkinsonGlobal Epidemiology and Modelling Group, University of Bristol, Bristol, UK.
Michael CurtisDisease Elimination, Burnet Institute, Melbourne, Australia.
Jason AsselinDisease Elimination, Burnet Institute, Melbourne, Australia.ORCID 0000-0003-0823-4816
Charles HendersonDisease Elimination, Burnet Institute, Melbourne, Australia.
Eric MakoniSchool of Health Research, Menzies and Charles Darwin University, Darwin, Australia.
Paul DietzeDisease Elimination, Burnet Institute, Melbourne, Australia.ORCID 0000-0001-7871-6234
Margaret HellardDisease Elimination, Burnet Institute, Melbourne, Australia.
Mark StoovéDisease Elimination, Burnet Institute, Melbourne, Australia.
Australian Collaboration for Coordinated Enhanced Sentinel Surveillance of Blood Borne Viruses and Sexually Transmissible Infections (ACCESS)

Funding

Australian Department of Health and Aged Care
6 · The paper itself

Abstract

introductionLong-acting injectable buprenorphine (LAIB) reduces the frequency of contact with opioid agonist therapy (OAT) service providers. Limited data exist on OAT prescribing in Australia after the introduction of subsidised LAIB prescribing in September 2019. This ecological study describes trends in OAT prescribing between 2015 and 2023 across a network of primary care services in Victoria, Australia.

methodsWe utilised electronic medical records from 17 clinics in Victoria that provide services to people with opioid dependence to describe OAT prescribing patterns. We described the annual number and type (methadone, buprenorphine, LAIB) of OAT prescriptions issued, individuals prescribed, and individuals initiating OAT. Interrupted time series assessed changes in quarterly OAT prescribing following the introduction of LAIB.

resultsBetween 2015 and 2023, the average annual number of OAT prescriptions issued, and the average number of recipients prescribed OAT were 47,648 and 6470, respectively. Between 2020 and 2023, the proportion of individuals initiating on LAIB increased from 7% (73/1078) to 31% (357/1146). There was increasing quarterly OAT prescribing before the introduction of LAIB, after which methadone and buprenorphine prescribing declined by 2.6% (CR 0.974; 95% CI 0.968-0.980) and 3.2% (CR 0.968; 95% CI 0.963-0.973), respectively. After being introduced, quarterly LAIB prescribing increased by 13.1% (CR 1.131; 95% CI 1.096-1.167). DISCUSSION AND

conclusionsWe found substantial changes in OAT prescribing patterns in Victoria between 2015 and 2023, with shifts away from oral methadone and sublingual buprenorphine to LAIB. Alongside ongoing monitoring of prescribing patterns, future research should assess how LAIB impacts patient health and social outcomes.

Indexed as

Analgesics, OpioidBuprenorphineOpiate Substitution TreatmentOpioid-Related DisordersPractice Patterns, Physicians'AdultDrug PrescriptionsFemaleHumansMaleMethadonePrimary Health CareVictoriaAnalgesics, OpioidBuprenorphineMethadonebuprenorphinemethadoneopiate substitution treatmentopioid agonist therapyopioid dependence

Identifiers

PMID40135426
PMCPMC12117301

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.