Evidence map›Paper›PMID 40135394›Full record

ArticlePhotochemistry and photobiology

Susceptibility of bacterial species commonly found in abdominal abscesses to low-dose photodynamic therapy: Effects of methylene blue concentration, fluence rate, and fluence.

Darrian S Hawryluk, Martin S Pavelka, Timothy M Baran

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Darrian S HawrylukDepartment of Biomedical Engineering, University of Rochester, Rochester, New York, USA.
Martin S PavelkaDepartment of Microbiology and Immunology, University of Rochester, Rochester, New York, USA.
Timothy M BaranDepartment of Biomedical Engineering, University of Rochester, Rochester, New York, USA.ORCID 0000-0002-4476-5609

Funding

Optical property measurement in human abscess cavities for photodynamic therapy treatment planningR01EB029921 · NIBIB · UNIVERSITY OF ROCHESTER · PI BARAN, TIMOTHY M · 2020 to 2023
$827k
Photodynamic therapy for perforated appendicitisR21AI178152 · NIAID · UNIVERSITY OF ROCHESTER · PI BARAN, TIMOTHY M, WILSON, NICOLE APRIL · 2023 to 2024
$411k
NIAID NIH HHS R21 AI178152NIBIB NIH HHS R01 EB029921NIH HHS AI178152NIH HHS EB029921
6 · The paper itself

Abstract

The objective of this study was to determine the effects of methylene blue (MB) concentration, laser fluence rate, and laser fluence on the efficacy of in vitro photodynamic therapy (PDT) for four bacteria commonly found in human abscesses. PDT experiments were performed with four of the most common bacteria found in abdominal abscesses: Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, and Pseudomonas aeruginosa. MB concentration was varied from 50 to 300 μg/mL, and the laser fluence rate was varied from 1 to 4 mW/cm

Indexed as

Abdominal AbscessMethylene BluePhotosensitizing AgentsDisease SusceptibilityDose-Response Relationship, RadiationEnterococcus faecalisEscherichia coliHumansPhotochemotherapyStaphylococcus aureusMethylene BluePhotosensitizing Agentsabscessantimicrobialfluencefluence ratemethylene bluephotodynamic therapy

Identifiers

PMID40135394
PMCPMC12353608

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.