ArticlePediatric transplantation2025
Inter-Dose Variability of Immunosuppressant Medication Among Adolescent Heart Transplants During Video Directly Observed Therapy.
Article in Pediatric transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Child and adolescent heart and lung post-transplant adherence.JHLT open · 2025Article
- Patient Engagement and Medication Consistency with Adolescent Heart Transplant Recipients.Proceedings. IEEE International Conference on Healthcare Informatics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundMedication adherence and timing of doses remains a challenge for adolescent patients following heart transplant. Mobile technology and adherence promotion efforts offer new avenues for direct observation of medication adherence and timeliness of medication-taking behavior. The study explores posttransplant medication maintenance, highlighting the importance of consistent dose timing with tacrolimus. The use of directly observed therapy (DOT) via a mobile health app was examined as a method for real-time medication monitoring, offered a platform for patients to upload videos of themselves taking medication for review by transplant team members.
methodsThe study examined a single-group design involving 10 adolescent heart transplant recipients over a 12-week DOT intervention, assessing both medication adherence and post-intervention outcomes.
resultsResults from multilevel regression models analyzing inter-dose timing and deviation from 12-h intervals revealed significant variability among patients and a correlation between increased deviation from the 12-h dose interval and both older patients and those with greater perceived barriers to medication adherence.
conclusionsFindings suggested a link between deviation from recommended dose timing and poorer posttransplant health outcomes. Findings underscored the potential of DOT and mobile health to examine timeliness of medication adherence, to directly observe medication-taking behavior, and association with posttransplant health outcomes.
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