ArticleWorld journal of emergency medicine2025
The role of early changes in routine coagulation tests in predicting the occurrence and prognosis of sepsis.
Article in World journal of emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Unfractionated Heparin and Low-Molecular-Weight Heparin in Sepsis: Anti-Inflammatory and Anticoagulant Effects Versus No Anticoagulation-A Propensity Score-Matched Analysis.Journal of clinical laboratory analysis · 2026Article
- Interpretable machine learning model predicts the early gastrointestinal dysfunction risk in severely burned patients: a multicenter-based study.International journal of surgery (London, England) · 2026Article
- A multimarker panel for diagnosis and prognosis prediction of fungal infections.Clinical and experimental medicine · 2026Article
- Risk factors and a nomogram for predicting severe acute kidney injury in pediatric sepsis: a retrospective study.Frontiers in pediatrics · 2026Article
- Explainable machine learning for predicting venous thromboembolism in septic shock patients.Frontiers in immunology · 2026Article
- Mechanisms of acquired resistance to osimertinib in EGFR T790M-Positive lung adenocarcinoma.Frontiers in genetics · 2026Article
- Predicting prognosis of sepsis in patients based on right ventricular strain imaging development and validation of a nomogram model.Frontiers in cardiovascular medicine · 2025Article
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7 authors.
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Abstract
backgroundThis study aimed to explore the importance of routine coagulation tests for the early detection of sepsis and to quickly identify patients at a high risk of mortality.
methodsThis retrospective single-center study collected data from patients meeting the clinical criteria for systemic inflammatory response syndrome (SIRS) with a confirmed infection source. Patients with coagulation disorders or on medications affecting coagulation were excluded. Patients were divided into sepsis and non-sepsis groups based on a Sequential Organ Failure Assessment (SOFA) score of ≥2. Univariate and multivariate logistic regression identified indicators from routine coagulation tests that predict sepsis. Prognostic roles of coagulation indicators were analyzed within the sepsis group.
resultsA total of 512 patients were included, with 396 in the sepsis group and 116 in the non-sepsis group. The predictive factors in the sepsis prediction model encompass fibrin degradation products (FDP), D-dimer, lactate, procalcitonin (PCT) levels and the utilization of mechanical ventilation. Early elevation of FDP and D-dimer levels predicted sepsis onset. The model exhibited an area under the curve (AUC) of 0.943 (95%
conclusionAbnormal high FDP and D-dimer levels in the early stages of sepsis provide a supplementary method for predicting sepsis. As the disease progresses, prolonged PT in the early stages of sepsis suggests a poor prognosis.
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