Evidence map›Paper›PMID 40135149›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD.

Chinenye C Odo, Joe Strong, Sarah R Lose, Yue Ma, Catherine L Gallagher, Barbara B Bendlin, Henrik Zetterberg, Kaj Blennow, Cynthia M Carlsson, Gwendlyn Kollmorgen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Chinenye C OdoDepartment of Medicine University of Wisconsin-Madison Madison Wisconsin USA.ORCID https://orcid.org/0009-0005-4580-5800
Joe StrongDepartment of Medicine University of Wisconsin-Madison Madison Wisconsin USA.
Sarah R LoseDepartment of Medicine University of Wisconsin-Madison Madison Wisconsin USA.
Yue MaDepartment of Medicine University of Wisconsin-Madison Madison Wisconsin USA.
Catherine L GallagherGeriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison Wisconsin USA.
Barbara B BendlinDepartment of Medicine University of Wisconsin-Madison Madison Wisconsin USA.
Henrik ZetterbergWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USA.
Kaj BlennowClinical Neurochemistry Laboratory Sahlgrenska University Hospital, Sahlgrenska, Mölndal Gothenburg Sweden.
Cynthia M CarlssonDepartment of Medicine University of Wisconsin-Madison Madison Wisconsin USA.
Gwendlyn KollmorgenRoche Diagnostics GmbH Penzberg Germany.
Clara Quijano-RubioRoche Diagnostics International Ltd Rotkreuz Switzerland.
Nathaniel A ChinDepartment of Medicine University of Wisconsin-Madison Madison Wisconsin USA.
Sanjay AsthanaDepartment of Medicine University of Wisconsin-Madison Madison Wisconsin USA.
Sterling C JohnsonDepartment of Medicine University of Wisconsin-Madison Madison Wisconsin USA.
Jacqueline Pontes MonteiroDepartment of Medicine University of Wisconsin-Madison Madison Wisconsin USA.
Ozioma C OkonkwoDepartment of Medicine University of Wisconsin-Madison Madison Wisconsin USA.

Funding

Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sanjay Asthana · 2019 to 2026
$34.5M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
White matter degeneration: biomarkers in preclinical Alzheimer's DiseaseR01AG037639 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI BENDLIN, BARBARA BRIGITTA · 2012 to 2023
$5.3M
Longitudinal Investigation of Cardiorespiratory Fitness and AD Biomarkers in an At-Risk CohortR01AG062167 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI OKONKWO, OZIOMA C · 2019 to 2023
$4.5M
NCRR NIH HHS UL1 RR025011NIA NIH HHS P30 AG062715NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG037639NIA NIH HHS R01 AG062167
6 · The paper itself

Abstract

introductionElevated cardiovascular rate pressure product (RPP) has been shown to predict cardiovascular mortality and is associated with poor cognitive test performance among older adults. However, it is unclear how RPP is related to the cerebrospinal fluid (CSF) biomarkers of neurodegeneration and neuroinflammation.

methodsRPP was cross-sectionally evaluated as a predictor of CSF biomarker levels in a cohort of 310 cognitively unimpaired late-middle-aged adults at risk for Alzheimer's disease. The primary outcomes were CSF levels of α-Synuclein, glial fibrillary acidic protein, neurofilament light (NfL), soluble triggering receptor expressed in myeloid cells 2, and total tau. Further analyses examined amyloid beta (Aβ)42/Aβ40, phosphorylated tau 181 (pTau181), and pTau181/Aβ4.

resultsRPP was positively associated with NfL (β = 0.006, DISCUSSION: A high myocardial oxygen demand at rest may be related to neuronal death and axonal degeneration in cognitively unimpaired late-middle-aged adults. Highlights: We explored the relationship between RPP and CSF analytes.Higher RPP was associated with higher NfL but not other measured CSF biomarkers.HR was positively associated with NfL, whereas SBP was not.

Indexed as

CSF biomarkersmyocardial oxygen demandNfLrate pressure productRPP

Identifiers

PMID40135149
PMCPMC11934293

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.