Evidence map›Paper›PMID 40135069›Full record

ArticleBrain communications2025

Interictal waking and sleep electrophysiological properties of the thalamus in focal epilepsies.

Tommaso Biagioni, Maria Fratello, Elodie Garnier, Stanislas Lagarde, Romain Carron, Samuel Medina Villalon, Isabelle Lambert, Angela Marchi, Julia Makhalova, Agnes Trebuchon and 5 more

Abstract read
In one paragraph

Article in Brain communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Tommaso BiagioniDepartment of Clinical and Experimental Medicine, University of Pisa, 56123 Pisa, Italy.ORCID https://orcid.org/0000-0002-6277-6213
Maria FratelloINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.
Elodie GarnierINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.
Stanislas LagardeINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.
Romain CarronINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.
Samuel Medina VillalonINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.
Isabelle LambertINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.
Angela MarchiAPHM, Timone Hospital, Sleep Unit, Epileptology and Cerebral Rhythmology, 13005 Marseille, France.
Julia MakhalovaINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.
Agnes TrebuchonINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.
Francesca BoniniINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.
Didier ScavardaINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.
Christian BenarINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.ORCID https://orcid.org/0000-0002-3339-1306
Fabrice BartolomeiINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.ORCID https://orcid.org/0000-0002-1678-0297
Francesca PizzoINSERM, INS, Inst Neurosci Syst, Aix Marseille Univ, 13005 Marseille, France.ORCID https://orcid.org/0000-0001-6345-1288

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epilepsy is a cortico-subcortical network disease. Thalamo-cortical relationships in focal epilepsies, studied by stereoelectroencephalography in complex patients during pre-surgical evaluation, might help refine epilepsy surgery prognostic indicators and patient-specific treatments (i.e. thalamic deep brain stimulation). To this aim, we studied interictal thalamic traces, during rest and sleep recordings, in a cohort of 121 patients, delving into thalamo-cortical connectivity, hyperexcitability biomarkers and their correlation with treatment outcome. We retrospectively gathered stereoelectroencephalography recordings and clinical variables from patients who underwent stereoelectroencephalography with mainly a posterior-thalamic implantation, aiming at the pulvinar. Interictal recordings during rest and sleep were analysed to detect spikes and fast ripples automatically. Functional connectivity between the thalamus and other brain regions (involved or non-involved in the epileptogenic network) was examined using linear regression analysis. Higher thalamic hyperexcitability biomarker rates during sleep were linked to unfavourable surgical outcomes (Engel Class III/IV) compared to favourable outcomes (Engel Class I/II) (spikes:

Indexed as

epileptogenic networksintracranial EEGsurgical outcomethalamic hyperexcitabilitythalamo-cortical functional connectivity

Identifiers

PMID40135069
PMCPMC11934066

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.