Evidence map›Paper›PMID 40135062›Full record

ArticleVirus evolution2025

Genomic variants and molecular epidemiological characteristics of dengue virus in China revealed by genome-wide analysis.

Bangyao Sun, Meng Xu, Lijia Jia, Haizhou Liu, Aixin Li, Lixia Hui, Zhitao Wang, Di Liu, Yi Yan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bangyao SunSchool of Medical Laboratory, Shandong Second Medical University, Baotong West Street 7166#, Weifang 261053, China.
Meng XuCAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Jinlong Street 262#, Wuhan 430207, China.
Lijia JiaCAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Jinlong Street 262#, Wuhan 430207, China.
Haizhou LiuCAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Jinlong Street 262#, Wuhan 430207, China.
Aixin LiSchool of Medical Laboratory, Shandong Second Medical University, Baotong West Street 7166#, Weifang 261053, China.
Lixia HuiSchool of Medical Laboratory, Shandong Second Medical University, Baotong West Street 7166#, Weifang 261053, China.
Zhitao WangSchool of Life Science and Technology, Shandong Second Medical University, Baotong West Street 7166#, Weifang 261053, China.
Di LiuCAS Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Jinlong Street 262#, Wuhan 430207, China.ORCID https://orcid.org/0000-0003-3693-2726
Yi YanDepartment of Respiratory Medicine, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hong Kong Road 100#, Wuhan 430015,China.ORCID https://orcid.org/0000-0001-8195-3628

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since its first academic record in 1978, dengue epidemics have occurred in all provinces of China, except Xizang. The epidemiological and molecular features of the whole genome of dengue virus (DENV) have not yet been completely elucidated, interfering with prevention and control strategies for dengue fever in China. Here, we obtained 553 complete genomes of the four serotypes of DENV (DENV1-4) isolated in China from the GenBank database to analyze the phylogeny, recombination, genomic variants, and selection pressure and to estimate the substitution rates of DENV genomes. Phylogenetic analyses indicated that DENV sequences from China did not cluster together and were genetically closer to those from Southeast Asian countries in the maximum likelihood trees, indicating that DENV was not endemic in China. Thirty intra-serotype recombinant sequences were identified for DENV1-4, with the highest frequency in DENV4. Selection pressure analyses revealed that 13 codons under positive selection were located in the C, NS1, NS2A, NS3, and NS5 proteins. For DENV1 to DENV3, the substitution rates evaluated in this study were 9.23 × 10

Indexed as

complete genomedengue virus in Chinaphylogenetic analysisrecombination detectionselection pressuresingle nucleotide polymorphism (SNP)substitution rate

Identifiers

PMID40135062
PMCPMC11934549

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.