Evidence map›Paper›PMID 40135007›Full record

ArticleCureus2025

Paraneoplastic Pemphigus in a Patient With Pheochromocytoma: A Report of a Rare Case.

Zhong-Zhou Huang, Ming-Jie He, Ping Huang, Min-Qing Luo, Dan Hong, Sha Lu, Qing Guo, Liangchun Wang, Hui Xiong

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhong-Zhou HuangDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, CHN.
Ming-Jie HeDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, CHN.
Ping HuangDepartment of Epidemiology and Public Health, School of Public Health, Sun Yat-sen University, Guangzhou, CHN.
Min-Qing LuoDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, CHN.
Dan HongDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, CHN.
Sha LuDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, CHN.
Qing GuoDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, CHN.
Liangchun WangDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, CHN.
Hui XiongDepartment of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, CHN.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report details a rare case of paraneoplastic pemphigus (PNP) associated with pheochromocytoma. The patient presented with prominent dermatological manifestations, including erythema, vesicles, and erosions. During hospitalization, diagnostic imaging revealed a retroperitoneal mass, which was subsequently surgically removed. A comprehensive diagnostic workup, including CT, MRI, histopathological analysis, and direct immunofluorescence examination, was conducted. Postoperative management combined with pharmacological intervention led to significant clinical improvement. This case highlights the critical importance of considering PNP in the differential diagnosis of pheochromocytoma, particularly in patients presenting with complex autoimmune manifestations. The findings underscore the necessity for early diagnosis and prompt therapeutic intervention in such cases. Additionally, this report emphasizes the need for further investigation into the clinical spectrum, genetic associations, and underlying mechanisms of this rare disease association to enhance diagnostic accuracy and therapeutic outcomes.

Indexed as

autoantibodyautoantigenautoimmune diseasesdesmogleinmethotrexatemethylprednisoloneparaneoplatic pemphiguspemphigus vulgarispheochromocytomarituximab

Identifiers

PMID40135007
PMCPMC11933724

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.