Evidence map›Paper›PMID 40134988›Full record

ArticleBioactive materials2025

A sequential drug delivery system based on silk fibroin scaffold for effective cartilage repair.

Menglin Xiao, Liangyan Sun, Kang Wu, Yuqi Ding, Peipei Wang, Chuangchuang Mu, Jinrong Yao, Zhengzhong Shao, Bingjiao Zhao, Xin Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Liquid-Responsive Shape-Memory Nanofiber-Reinforced Scaffolds for Cartilage Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Recent Advances in Silk Fibroin Derived fromJournal of functional biomaterials · 2025
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Menglin XiaoDepartment of Macromolecular Science, Department of Orthodontics, Multidisciplinary Consultant Center, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200433, China.
Liangyan SunDepartment of Macromolecular Science, Department of Orthodontics, Multidisciplinary Consultant Center, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200433, China.
Kang WuDepartment of Macromolecular Science, Department of Orthodontics, Multidisciplinary Consultant Center, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200433, China.
Yuqi DingDepartment of Macromolecular Science, Department of Orthodontics, Multidisciplinary Consultant Center, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200433, China.
Peipei WangDepartment of Macromolecular Science, Department of Orthodontics, Multidisciplinary Consultant Center, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200433, China.
Chuangchuang MuDepartment of Macromolecular Science, Department of Orthodontics, Multidisciplinary Consultant Center, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200433, China.
Jinrong YaoDepartment of Macromolecular Science, Department of Orthodontics, Multidisciplinary Consultant Center, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200433, China.
Zhengzhong ShaoDepartment of Macromolecular Science, Department of Orthodontics, Multidisciplinary Consultant Center, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200433, China.
Bingjiao ZhaoDepartment of Macromolecular Science, Department of Orthodontics, Multidisciplinary Consultant Center, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200433, China.
Xin ChenDepartment of Macromolecular Science, Department of Orthodontics, Multidisciplinary Consultant Center, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai, 200433, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endogenous repair of cartilage defects is a preferential strategy for cartilage repair, but always hindered by insufficient early-stage cells and incomplete cell differentiation at later stages. For

Indexed as

Cartilage repairChondrogenesisRecruitmentSequential drug releaseSilk protein

Identifiers

PMID40134988
PMCPMC11932872

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.