ArticleFrontiers in cardiovascular medicine2025
The effect of HA380 blood adsorption on patients with acute infective endocarditis undergoing cardiac surgery: a retrospective study.
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Septic Shock and Rhabdomyolysis as Rare Complications Following Rectal Perforation: A Case Report.International medical case reports journal · 2026Article
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10 authors.
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Abstract
Introduction: Sepsis is a major cause of ICU admission and mortality in patients with infective endocarditis patients. This study aimed to explore the effect of intraoperative HA380 blood adsorption on surgical outcomes in infective endocarditis patients, given its ability to adsorb inflammatory factors. Methods: We retrospectively analyzed the clinical data of patients who underwent surgical treatment for infective endocarditis at our hospital. After propensity score matching, eligible patients were matched in a 1:1 ratio between HA380 users and non-users. The primary endpoint was the incidence of postoperative sepsis, while secondary outcomes included ICU stay, postoperative hospital stay, and the need for CRRT, IABP, and ECMO therapies. Laboratory results were compared at 24, 48, and 72 h postoperatively. Results: A total of 148 patients were included in the analysis. After 1:1 matching, 39 pairs were further analyzed. There was no significant difference in the incidence of postoperative sepsis (20.5% vs. 15.4%, Discussion: This study did not demonstrate a reduced risk of postoperative sepsis with HA380 blood adsorption. Although the HA380 group had a shorter postoperative hospital stay, lower fibrinogen levels, and a higher albumin-to-fibrinogen ratio, the overall effectiveness of HA380 requires further investigation.
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