Evidence map›Paper›PMID 40134838›Full record

ArticleWorld journal of virology2025

Septic shock due to cytomegalovirus colitis associated with rituximab use: A case report.

Siddharth Patel, Jordan Jay, Prutha Pathak, Mc Anto Antony, Mrudula Thiriveedi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Siddharth PatelDepartment of Internal Medicine, Decatur Morgan Hospital, Decatur, AL 35601, United States. sidd8801@gmail.com.
Jordan JayDepartment of Medicine, Alabama College of Osteopathic Medicine, Dothan, AL 36303, United States.
Prutha PathakDepartment of Internal Medicine, North Alabama Medical Center, Florence, AL 35630, United States.
Mc Anto AntonyDepartment of Endocrinology, Diabetes and Metabolism, Medical University of South Carolina/AnMed Campus, Anderson, SC 29621, United States.
Mrudula ThiriveediDepartment of Internal Medicine, Decatur Morgan Hospital, Decatur, AL 35601, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCytomegalovirus (CMV) infections can cause significant morbidity and mortality in immunocompromised individuals. CMV targets dysfunctional lymphocytes. Chronic rituximab (RTX) therapy can cause B-lymphocyte dysfunction, increasing CMV risk. Rarely, CMV infections present with critical illness such as septic shock. CASE SUMMARY: A 64-year-old African American woman presented with generalized weakness and non-bloody watery diarrhea of 4-6 weeks duration. She did not have nausea, vomiting or, abdominal pain. She had been on monthly RTX infusions for neuromyelitis optica. She was admitted for septic shock due to pancolitis. Blood investigations suggested pancytopenia and serology detected significantly elevated CMV DNA. Valganciclovir treatment led to disease resolution.

conclusionThis case illustrates an extremely rare case of CMV colitis associated with RTX use presenting with septic shock. High suspicion for rare opportunistic infections is imperative in individuals with long-term RTX use.

Indexed as

Case reportCytomegalovirus colitisImmunocompromised statusPancytopeniaRituximab useSeptic shock

Identifiers

PMID40134838
PMCPMC11612876

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