ArticleAmerican journal of clinical and experimental immunology2025
The prognostic significance of FMR1 expression and its immunomodulatory implications in esophageal carcinoma.
Article in American journal of clinical and experimental immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Fragile X mental retardation 1 gene FMR1 promotes proliferation, migration, and invasion of gastric cancer cells via c-MYC.Journal of translational medicine · 2025Article
- IGLL5 has potential to be a prognostic biomarker and its correlation with immune infiltrates in breast cancer.American journal of clinical and experimental immunology · 2025Article
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9 authors.
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Abstract
backgroundEsophageal carcinoma (ESCA) is deemed a highly lethal malignancy with a grim prognosis and stands as the fourth leading cause of cancer-related mortality. Recent research has revealed the potential crucial role of fragile X mental retardation 1 (FMR1) protein in tumor development and progression. However, the correlation between FMR1 and immune regulation in ESCA remains unclear. In this study, we aimed to assess the clinicopathological and prognostic significance of FMR1 expression, and its relationship with immune cell infiltration, immune biomarkers and the pathway involved in ESCA.
methodsThe Cancer Genome Atlas (TCGA) pan-cancer data and the Gene Expression Omnibus (GEO) database were used to analyze the expression of FMR1. The correlation between FMR1 and cancer stage, time-dependent survival curve and receiver operating characteristic (ROC) curve were performed using R package. Immune cell infiltration was assessed using the samples found in TCGA. Functional enrichment analyses were performed to investigate the potential signaling pathway and biological functions.
resultsFMR1 was upregulated in 7 tumors and downregulated in 4 tumors. Overexpression of FMR1 considerably associated with cancer stage and poor prognosis in ESCA. The ROC area was 0.745 and 0.830 for 3-year and 5-year respectively. FMR1 exhibited a positive correlation with common lymphoid progenitor and T cell CD4+ Th2, and a negative correlation with B cell memory, B cell plasma, endothelial cell, monocyte, neutrophil, T cell CD4+ Th1, and T cell CD4+ effector memory in ESCA. The enrichment analysis revealed FMR1 was primarily associated with cell development and predominantly enriched in immune-related pathways.
conclusionFMR1 may act as a prognostic biomarker for ESCA and participate in immune regulation in ESCA.
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