ArticleFrontiers in cellular and infection microbiology2025
Adaptive attenuation of virulence mediated by Wzc mutation in ST11-KL47 Carbapenem-resistant
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Post-infection colonization and recurrent infections by ST11-KL64 carbapenem-resistantVirulence · 2026Article
- Transcriptomic correlates of ceftazidime-avibactam collateral sensitivity in tigecycline-resistant NDM-producing enterobacter cloacae complex.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Wzc mutation enhances virulence in CRKP ST11-KL64 via complement-mediated lysis and lipopolysaccharide release.Microbiology spectrum · 2026Article
- Comparative genomic, phenotypic, and clinical characterization of ST11-KL25 and ST11-KL64 hypervirulent carbapenem-resistantAntimicrobial agents and chemotherapy · 2026Article
- How Klebsiella pneumoniae controls its virulence.PLoS pathogens · 2025Review
- TheFrontiers in microbiology · 2025Article
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Authors and funding
9 authors.
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Abstract
Introduction: The impact of the hypermucoviscosity (HMV) phenotype in ST11-KL47 carbapenem-resistant Methods: We analyzed 230 clinical ST11-KL47 CRKp to identify the key factor in mucoviscosity acquisition via comparative genomic analysis. Sedimentation value served as the objective index to quantify HMV. The virulence Results: The Wzc mutations are identified as the key to mucoviscosity acquisition. Unexpectedly, Wzc-mediated HMV CRKp exhibits reduced pathogenicity versus non-mucoviscosity (NMV) strains in different animal models, with competitive disadvantage, decreased biofilm formation, serum resistance, and adhesion, yet higher anti-phagocytic ability Discussion: These findings demonstrate that the Wzc-induced HMV attenuates ST11-KL47 CRKp virulence by modifying the exopolysaccharide composition and physical distribution.
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