ReviewFrontiers in genetics2025
Bibliometric analysis of case-control studies on the association between HLA alleles and multiple sclerosis in adults.
Review in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Multiple sclerosis (MS) is a complex autoimmune disease that affects the central nervous system (CNS) with genetic and environmental factors playing a significant role in its development and progression. One of the most important genetic factors associated with MS is the HLA gene complex. The relationship between HLA and MS has been the subject of numerous studies, but no bibliometric analysis of this research has been reported to date. Therefore, this study aimed to provide a comprehensive overview of the publication output, citation impact, collaboration patterns, and research topics related to HLA and MS. Methods: A bibliometric analysis of 488 studies published between 1988 and 2023 was conducted using RStudio, Tableau and VOSviewer software. Results: The results indicated an increasing trend in the number of publications and citations over time, with the highest productivity and impact coming from researchers in the United States, Italy and Sweden. The analysis also revealed collaboration networks among researchers and institutions, with the most common research topics being the association of HLA alleles with MS susceptibility, disease course, and treatment response. This study's limitations stem from the inherent biases associated with bibliometric analysis, including database and coverage bias, citation bias, and biases related to accessibility and open access. Additionally, the exclusion of non-English language articles represents a further limitation. Conclusion: Overall, this bibliometric analysis provides valuable insight into the research landscape of HLA and MS, highlighting the areas that have received the most attention and identifying potential avenues for future research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.