ReviewRSC advances2025
Cortistatin and plakinamine steroidal alkaloids from the marine sponges of the genus
Review in RSC advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Tides of Promise: Sponge-Derived Marine Natural Products in Southeast Asia.Molecules (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortistatins and plakinamines represent a unique class of marine-derived steroidal alkaloids, renowned for their structural diversity and potent pharmacological activities. This review provides a comprehensive overview of their chemical characteristics, pharmacological profiles, pharmacokinetics, and drug-likeness properties, with a particular focus on structure-activity relationships (SARs). Indeed, we explored their distinct molecular architectures and classification within the broader family of marine alkaloids, highlighting key subclasses and derivatives identified through advanced analytical techniques. Their broad-spectrum bioactivities, including anticancer, anti-inflammatory, antimicrobial, and antiviral effects, are discussed in detail, supported by insights into SARs and pharmacophore identification that illuminate the molecular basis of their bioactivity. Additionally, we evaluate their pharmacokinetic attributes, including absorption, distribution, metabolism, and elimination (ADME), alongside their compliance with drug-likeness criteria, offering a holistic perspective on their potential for drug development.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.