ArticleFrontiers in aging neuroscience2025
Alteration of prefrontal functional connectivity in preclinical Alzheimer's disease: an fNIRS study.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic potential of near-infrared spectroscopy in mild cognitive impairment and neurodegenerative disorders: Implications for resource-limited settings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Pooled it
- Sulcal depth-based individualized structural covariance networks reveal multi-level brain reorganization associated with cognitive performance in COPD.Frontiers in neuroscience · 2026Article
- A systematic review and meta-analysis on dual-task sensor-based motion analysis for dementia detection.Frontiers in digital health · 2026Review
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7 authors.
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Abstract
Background: Early detection of Alzheimer's disease (AD) is vital for delaying its progression through timely intervention. The preclinical stage, the longest phase of AD, often goes undetected due to a lack of noticeable symptoms. Developing an accessible and quantitative screening method for AD is essential for enabling appropriate interventions during this stage. Methods: Functional near-infrared spectroscopy was used to investigate prefrontal functional connectivity in preclinical AD subjects. A total of 99 participants, including healthy controls and preclinical subjects who were amyloid beta (Aβ) positive ( Results: The preclinical AD group exhibited increased interhemispheric functional connectivity derived from oxygenated and deoxygenated hemoglobin during verbal tasks involving the first phonemic letter. Additionally, significant right and left functional connectivity differences were observed in the healthy control group during verbal tasks with the letter and categories, but not in the preclinical AD group. Lastly, the difference in interhemispheric functional connectivity of oxygenated hemoglobin between the first and second verbal trials was significantly greater in the preclinical AD group. These interhemispheric functional connectivity values were significantly correlated with Aβ results from positron emission tomography. Conclusion: The initial increase and subsequent reduction of interhemispheric functional connectivity in the preclinical AD group across task repetitions suggests that task-related prefrontal network alterations may occur during the preclinical phase of AD and shows its potential as a biomarker for screening preclinical AD.
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