Evidence map›Paper›PMID 40134509›Full record

ArticleThe journal of physical chemistry. C, Nanomaterials and interfaces2025

Electrokinetic Motion of Neurotransmitter Ions through a 1.01 nm Diameter Single-Walled Carbon Nanotube.

Mark D Ellison, Jacqueline Allen, Michael Bonfiglio, Matthew Seeburger, Jean Setenet, Biagio DiGinto, Harrison Bonanny, Aaliyah Russell, David Baird, Liana Davis and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. C, Nanomaterials and interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mark D EllisonDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.ORCID https://orcid.org/0000-0003-3201-8478
Jacqueline AllenDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Michael BonfiglioDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Matthew SeeburgerDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Jean SetenetDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Biagio DiGintoDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Harrison BonannyDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Aaliyah RussellDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
David BairdDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Liana DavisDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Ella McCarthyDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Alyson ManleyDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Sarah BlattDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
David LippeDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Daniel RagoneDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Brock DyerDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Jillian OsgoodDepartment of Chemistry, Ursinus College, 601 E. Main St., Collegeville, Pennsylvania 19426, United States.
Michael S StranoDepartment of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave., Cambridge, Massachusetts 02139, United States.ORCID https://orcid.org/0000-0003-2944-808X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The transport of cations of the neurotransmitters acetylcholine, choline, and dopamine through a 1.01 nm-diameter, 1.1 mm-long single-walled carbon nanotube (SWNT) has been studied for the first time. As a comparison, sodium and aniline ion transport was also investigated. All of these ions exhibited significantly enhanced electrophoretic mobilities over bulk transport. The electrophoretic mobilities of acetylcholine, choline, and sodium were found to depend on pH, specifically increasing as pH decreases. This result is explained by hydrogen ions saturating the surface charges of the SWNT. Conversely, dopamine and aniline have mobilities that do not depend on pH. This difference is attributed to the benzene ring and the size of these ions. An analysis of the time required for an ion to traverse the nanotube shows that the ions adsorb to and desorb from the walls as they pass through the tube. Acetylcholine, choline, and sodium show desorption rate constants that decrease with increasing pH, whereas dopamine and aniline have rate constants that remain constant over different pH values. This is consistent with the relationship between adsorption and desorption rate constants and mobility from an adsorption/desorption kinetic model.

Identifiers

PMID40134509
PMCPMC11931543

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.