ArticleJournal of medicine and life2025
The real-world anti-inflammatory effect of SGLT2i in patients with chronic heart failure.
Article in Journal of medicine and life, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Neural-immune-cardiovascular axis: from mechanistic crosstalk to therapeutic targets in cardiovascular disease.Frontiers in immunology · 2026Review
- C-reactive protein in cardiovascular disease: clinical associations, conformation-dependent biology, and therapeutic perspectives.Frontiers in immunology · 2026Review
- Analysis of the value of nutritional status indexes (ALB, Hb, GNRI) in prognostic assessment of elderly patients with chronic heart failure.Frontiers in cardiovascular medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation plays a major role in the etiology of chronic heart failure and in inducing the progression to end-stage heart failure. This chronic inflammation, which accompanies heart failure, is not only local but also systemic and is usually in a state of low-grade but constant activation. Because there is an interrelation between systemic inflammation and neurohormonal activation, almost all anti-remodeling classes of medication have been evaluated for a potential and hidden anti-inflammatory effect. This study aimed to evaluate the effect of sodium-glucose co-trans-porter 2 inhibitors (SGLT2i) (Dapagliflozin or Empagliflozin) on inflammation measured by C-reactive protein levels, erythrocyte sedimentation rate (ESR) and fibrinogen in patients with chronic heart failure when administered together with other standard heart failure medications. We retrospectively enrolled 220 patients with chronic heart failure admitted to our hospital from January 2021 until March 2023. The study included two visits, T0 (the initial visit) and T1 (after six months), to assess if SGLT2i initiation after the first visit (T0) had an effect on the levels of inflammatory biomarkers. SGLT2i showed a reduction in fibrinogen levels, an effect that was present both in heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) phenotypes. This was opposite to the dynamics of inflammatory markers in patients who did not receive SGLT2i, where the fibrinogen levels increased in HFrEF and HFpEF subgroups. SGLT2i proved an anti-inflammatory effect, showing a statistically significant reduction in fibrinogen levels in chronic heart failure, irrespective of the phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.