ArticleJournal of Indian Society of Periodontology
Effect of exposure to the carcinogen 50 ppm 4-nitroquinoline 1-oxide on alveolar bone loss.
Article in Journal of Indian Society of Periodontology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Background: The objective of this study was to analyze the effect of exposure to the carcinogen 4-nitroquinoline 1-oxide (4NQO), with or without experimental periodontitis (EP), on alveolar bone loss (ABL) in rats. Materials and Methods: Male Wistar rats ( Results: All animals exposed to 4NQO presented macroscopic lesions on the tongue. When considering the side with EP, no statistically significant difference was demonstrated between Groups 3 (median: 0.76; intervals interquartile [IQ]: 0.42-0.45) and 4 (median: 0.78; IQ: 0.70-0.80). In the side without EP, Group 4 (median: 0.51 mm; IQ: 0.45-0.70) presented significantly higher ABL compared to Group 1 (median: 0.41 mm; IQ: 0.38-0.43). Group 3 (median: 0.44; IQ: 0.41-0.47) showed no significant difference when compared to Groups 1 (median: 0.41; IQ: 0.38-0.43) and 2 (median: 0.46; IQ: 0.41-0.54). Conclusions: It was concluded that higher ABL occurred in the presence of a carcinogen. However, the combination of both 4NQO and EP did not promote higher ABL.
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