SynthesisThe American journal of psychiatry2025
High-Potency Cannabis Use and Health: A Systematic Review of Observational and Experimental Studies.
Synthesis in The American journal of psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Adolescent cannabis use disorder following recreational cannabis legalization in California, USA: A population-based interrupted time series study.Addiction (Abingdon, England) · 2026Article
- International Policy Approaches for Higher THC Cannabis Products: Are They Applicable to the Australian Medicinal Cannabis Framework?Drug and alcohol review · 2026Review
- Crossed Pathways: Tobacco-Cannabis Co-Use and Motivation to Quit in Young Adults in France.Drug and alcohol review · 2026Article
- Cannabis modalities matter for momentary subjective drug effects.Addictive behaviors · 2026Article
- An update on cannabis products, cannabinoid content, plant type, and prices five years after legalization in Ontario, Canada.Journal of cannabis research · 2026Article
- Changes in cannabis potency and cannabis-related psychiatric harms: a 23-year ecological study in Denmark.Psychological medicine · 2026Article
- Higher THC Concentration Medicinal Cannabis Products Efficacy and Safety Considerations: A Rapid Review.Drug and alcohol review · 2026Review
- Higher risk cannabis use indicators among people living in Canada: a cross-sectional study examining the association with socio-demographic and socio-economic factors.Substance abuse treatment, prevention, and policy · 2026Article
- Rewired realities: novel insights into the neurobiology of cannabis use disorder and psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Perceptions of cannabis among adults aged 60 years and older in Canada: a qualitative study.Health promotion and chronic disease prevention in Canada : research, policy and practice · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectiveAmid continuously rising concentrations of delta-9-tetrahydrocannabinol (THC) in cannabis (i.e., potency), high-potency cannabis is a major topic in contemporary cannabis policy discussions, yet its impact on health is not well understood. The authors conducted a systematic review of observational and experimental studies examining the relationship between high-potency cannabis use and a range of health outcomes.
methodsRecords were obtained from a systematic search of five biomedical research databases. The authors developed ecologically relevant potency (percent THC) exposure-comparison categories (1%-9%, 10%-19%, 20%-30%, kief/resin [∼30%-50%], concentrates [≥60%]) and used a landmark scientific report on cannabis and cannabinoids to determine outcome eligibility. Two reviewers independently conducted article screening and selection, extraction, and quality assessment. Findings were synthesized using both quantitative (association direction, binomial test) and narrative approaches. Certainty in the evidence was determined via the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework.
resultsOf 4,545 screened records, 42 were eligible. Most studies addressed outcomes in the mental health, "problem" cannabis use, and other substance use domains. Findings in the "problem" cannabis use domain were suggestive of an association with higher-potency cannabis use. Findings were less consistent in other domains but tended to favor poorer outcomes with higher-potency use. Therapeutic outcomes were limited and mixed. Overall, certainty in the evidence was "very low."
conclusionsFindings within the "problem" cannabis use domain were suggestive of an association with high-potency use. Research is largely limited to cross-sectional studies spanning few adverse health domains, underscoring the need for prospective studies probing therapeutic, cardiorespiratory, cancer, and pre- and perinatal outcomes. Policies to curb high-potency cannabis use may be warranted while the evidence base improves.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.