Evidence map›Paper›PMID 40134056›Full record

Trial reportAsia Pacific journal of clinical nutrition2025

Mulberry leaves and water chestnut tea reduces postprandial blood glucose in borderline diabetic Japanese: A randomized, double-blind, placebo-controlled crossover study.

Midori Yasuda, Kenichiro Yasutake, Iori Yoshinaga, Kanako Nakashima, Madoka Saiki, Ai Takeyama-Mitsuta, Tatsuya Doi

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Asia Pacific journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Midori YasudaDepartment of Health and Nutrition Sciences, Nishikyushu University, Saga, Japan.
Kenichiro YasutakeDepartment of Nutritional Sciences, Nakamura Gakuen University, Fukuoka, Japan.
Iori YoshinagaDepartment of Nutritional Sciences, Nakamura Gakuen University Junior College, Fukuoka, Japan.
Kanako NakashimaDepartment of Health and Nutrition Sciences, Nishikyushu University, Saga, Japan.
Madoka SaikiDepartment of Health and Nutrition Sciences, Nishikyushu University, Saga, Japan.
Ai Takeyama-MitsutaDepartment of Health and Nutrition Sciences, Nishikyushu University, Saga, Japan.
Tatsuya DoiDepartment of Life Support Science, Graduate School of Nishikyushu University, Saga, Japan.

Funding

Kanzaki-shi, Saga, Japan "Product Development Research Grant" for 2018-2022
6 · The paper itself

Abstract

BACKGROUND AND

objectivesPostprandial hyperglycemia is a risk factor not only for diabetes mellitus, but also arteriosclerosis. Therefore, controlling the rapid postprandial increase in blood glucose levels is necessary. This study aimed to develop a mulberry leaf and water chestnut husk tea and investigate its effect on postprandial blood glucose levels. METHODS AND STUDY

designWe measured the polyphenols and 1-deoxynojirimycin contents as well as antioxidant activity of mulberry leaf and water chestnut husk tea in an in vitro experiment. The effect of the tea on postprandial blood glucose levels in 30 participants with borderline diabetes was investigated in a randomized, double-blind, placebo-controlled crossover comparison study.

resultsThe 1-deoxynojirimycin and total polyphenol contents in the tea (test food, 3g) were 10.2±0.8 and 61.3±1.4 mg, respectively. The test food showed higher antioxidant activity than the placebo food. Compared with those in the placebo group, blood glucose levels in the test group significantly decreased 30 and 60 min after eating rice. Additionally, insulin was significantly lower at all time points (30, 60, 90, and 120 min after rice consumption).

conclusionsThe mulberry leaves and water chestnut mix tea may be an effective beverage to reduce insulin secretion and prevent rapid increases in blood glucose levels in patients with borderline diabetes.

Indexed as

Blood GlucoseFagaceaeMorusPlant LeavesAdultAntioxidantsBeveragesCross-Over StudiesDouble-Blind MethodEast Asian PeopleFemaleHumansJapanMaleMiddle AgedPolyphenolsAntioxidantsBlood GlucosePolyphenols1-deoxynojirimycinmulberry leavespolyphenolspostprandial blood glucose levelwater chestnut

Identifiers

PMID40134056
PMCPMC11937486

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.