ArticleBMC research notes2025
Failure to prevent classical scrapie after repeated decontamination of a barn.
Article in BMC research notes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Chronic Wasting Disease in Farmed Cervids, South Korea, 2001-2024.Emerging infectious diseases · 2026Article
- Prions and protein aggregates as pathogens, self-propagating structures, biomarkers, and therapeutic targets.Microbiology and molecular biology reviews : MMBR · 2025Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivePrions, the causative agent of scrapie in sheep, are extremely resistant to disinfection and can remain biologically active for years, which makes it challenging to prevent re-infection of susceptible animals on farms after a scrapie outbreak. The present study investigated the effectiveness of disinfection of a barn that previously housed scrapie-affected sheep as part of the husbandry of scrapie infected sheep on the farm. The barn was decontaminated with sodium hypochlorite for four times the recommended exposure time. Two cohorts, consisting of 25 and 21 sheep, with susceptible prion protein genotypes (VRQ/VRQ), born 2 years apart, were housed in the barn and infection monitored by examination of rectal biopsies.
resultsOne sheep from the first cohort and four from the second were found to be infected from 775 (first cohort) and 550 days (second cohort) post exposure. It is concluded that decontamination with sodium hypochlorite at the recommended concentration and longer exposure time did not prevent re-infection of susceptible sheep. Disinfection of contaminated premises to eradicate scrapie continues to be a challenge.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.