Evidence map›Paper›PMID 40134016›Full record

ArticleBiotechnology for biofuels and bioproducts2025

Combining biosensor and metabolic network optimization strategies for enhanced L-threonine production in Escherichia coli.

Zhenqiang Zhao, Rongshuai Zhu, Xuanping Shi, Fengyu Yang, Meijuan Xu, Minglong Shao, Rongzhen Zhang, Youxi Zhao, Jiajia You, Zhiming Rao

Abstract read
In one paragraph

Article in Biotechnology for biofuels and bioproducts, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Synthetic and systems biotechnology · 2026
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhenqiang Zhao *Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Rongshuai Zhu *Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Xuanping ShiKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Fengyu YangKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Meijuan XuKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Minglong ShaoKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Rongzhen ZhangKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu, China.
Youxi ZhaoCollege of Biochemical Engineering, Beijing Union University, Beijing, 100023, China.
Jiajia YouKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu, China. youjiajia@jiangnan.edu.cn.
Zhiming RaoKey Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, 214122, Jiangsu, China. raozhm@jiangnan.edu.cn.

Funding

The National First-class Discipline Program of Light Industry Technology and Engineering QGJC20230201The National Key Research and Development Program of China 2021YFC2100900The National Natural Science Foundation of China 32071470The Open Funding Project of Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University KLIB-KF202102The Program of Introducing Talents of Discipline to Universities (111-2-06) and Postgraduate Research & Practice Innovation Program of Jiangsu Provence KYCX22-2369
6 · The paper itself

Abstract

L-threonine is an integral nutrient for mammals, often used in animal feeds to enhance growth and reduce breeding costs. Developing L-threonine engineered strains that meet industrial production specifications has significant economic value. Here, we developed a biosensor that monitors L-threonine concentration to assist in high-throughput screening to capture high-yielding L-threonine mutants. Among them, the P

Indexed as

Directed evolutionHigh-throughputIn silico simulationl-Threonine biosensorMulti-omics analysis

Identifiers

PMID40134016
PMCPMC11938683

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.