Evidence map›Paper›PMID 40133959›Full record

ArticleJournal of nanobiotechnology2025

Radiation-induced ferroptosis via liposomal delivery of 7-Dehydrocholesterol.

Jianwen Li, Shuyue Zhan, Wei Yang, He Zhang, Xinrui Ma, Fanghui Chen, Amy Li, Pakteema Tong, Fangchao Jiang, Zhengwei Cao and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jianwen LiDepartment of Chemistry, University of Georgia, Athens, GA, 30602, USA.
Shuyue ZhanDepartment of Chemistry, University of Georgia, Athens, GA, 30602, USA.
Wei YangDepartment of Chemistry, University of Georgia, Athens, GA, 30602, USA.
He ZhangDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Xinrui MaDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Fanghui ChenDepartment of Hematology and Medical Oncology & Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Amy LiDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, 98195, USA.
Pakteema TongDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, 98195, USA.
Fangchao JiangDepartment of Chemistry, University of Georgia, Athens, GA, 30602, USA.
Zhengwei CaoDepartment of Chemistry, University of Georgia, Athens, GA, 30602, USA.
Ian DelahuntyDepartment of Chemistry, University of Georgia, Athens, GA, 30602, USA.
Jiayi WangDepartment of Chemistry, University of Georgia, Athens, GA, 30602, USA.
Yufei WuDepartment of Chemistry, University of Georgia, Athens, GA, 30602, USA.
Zhi LiuDepartment of Chemistry, University of Georgia, Athens, GA, 30602, USA.
Zibo LiDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Yong TengDepartment of Hematology and Medical Oncology & Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, 30322, USA.
Libin XuDepartment of Medicinal Chemistry, University of Washington, Seattle, WA, 98195, USA.
Jin XieDepartment of Chemistry, University of Georgia, Athens, GA, 30602, USA. jinxie@uga.edu.

Funding

Winship Cancer Institute Cancer Center Support GrantP30CA138292 · NCI · EMORY UNIVERSITY · PI Suresh S Ramalingam · 2009 to 2026
$47.5M
The development of novel radiation-sensitizer based on ultra-small carbon dotsR01CA247769 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, ZIBO, XIE, JIN · 2020 to 2024
$2.5M
Development of a novel biodegradable inorganic nanoparticle therapeutic for cancerR01CA257851 · NCI · UNIVERSITY OF GEORGIA · PI KIM, WILLIAM Y., LI, ZIBO · 2021 to 2024
$2.1M
Oxysterols in SLOS Neurodevelopment: Pathological Role and TherapyR01HD092659 · NICHD · UNIVERSITY OF WASHINGTON · PI XU, LIBIN · 2017 to 2021
$1.9M
ATAD3A as a Novel Target in Head and Neck CancerR01DE028351 · NIDCR · EMORY UNIVERSITY · PI TENG, YONG · 2019 to 2023
$1.9M
Congressionally Directed Medical Research Programs R01DE028351NCI NIH HHS P30 CA138292NCI NIH HHS R01 CA247769NCI NIH HHS R01CA247769, R01CA257851NCI NIH HHS R01 CA257851NICHD NIH HHS R01 HD092659NIDCR NIH HHS R01 DE028351NIEHS NIH HHS R01HD092659Winship Cancer Institute P30CA138292
6 · The paper itself

Abstract

backgroundFerroptosis is an emerging cell death mechanism characterized by uncontrolled lipid peroxidation. However, selectively inducing ferroptosis in cancer cells remains a challenge.

methodsWe explore an approach that enables ferroptosis induction through external radiation. The key component of this technology is 7-dehydrocholesterol (7DHC), a natural biosynthetic precursor of cholesterol. To facilitate delivery, we demonstrate that 7DHC, like cholesterol, can be incorporated into the lipid layer of liposomes. To enhance targeting, we also introduced NTS

resultsUnder radiation, 7DHC reacts with radiation-induced reactive oxygen species (ROS), initiating a radical chain reaction with polyunsaturated fatty acids (PUFAs) in cell membranes. This process results in direct lipid peroxidation and subsequent ferroptotic cell death. In vivo studies demonstrate that NTS

conclusionWhile conventional radiosensitizers primarily target DNA and its repair mechanisms, our study introduces a strategy to enhance radiotherapy by specifically activating ferroptosis within the irradiated area, thereby minimizing systemic toxicity. Such a strategy of controlled activation of ferroptosis offers a favorable therapeutic index and potentially opens avenues for clinical application.

Indexed as

DehydrocholesterolsFerroptosisLiposomesAnimalsCell Line, TumorHumansLipid PeroxidationMiceRadiation-Sensitizing AgentsReactive Oxygen Species7-dehydrocholesterolDehydrocholesterolsLiposomesRadiation-Sensitizing AgentsReactive Oxygen Species7-dehydrocholesterolFerroptosisLipid peroxidationLiposomesRadiosensitizer

Identifiers

PMID40133959
PMCPMC11938788

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.