ArticleBMC public health2025
Trajectories of health status and their association with rheumatoid arthritis risk: insights from a national prospective cohort study.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Association between the sarcopenia index and osteoarthritis: a cross-sectional and longitudinal study.European journal of medical research · 2026Article
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5 authors.
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Abstract
backgroundThe association between trajectories of different health states and rheumatoid arthritis (RA) is unknown. Our cohort study aimed to investigate the impact of various trajectories (including depressive symptoms, physical activity and multimorbidity status) on subsequent RA risk.
methodsA prospective cohort study was conducted using seven waves of national data from the Health and Retirement Study (HRS 2004-2018) involving 9,795 US adults. A growth mixture model identified 6-year trajectories from 2004 to 2010, and participants were screened for RA by self-reported physician diagnosis in the subsequent four waves (2010-2018). Cox proportional hazards model calculated hazard ratios (HR).
resultsTrajectories of depressive symptoms, physical activity, and multimorbidity status were all associated with the risk of RA. Specifically, keeping a low trajectories (HR = 0.649, 95%CI = 0.533-0.790) or maintaining a moderate rating trajectories (HR = 0.798, 95%CI = 0.644-0.988) for depressive reduced the risk of RA. For physical activity, both high and descending trajectories (HR = 1.456, 95%CI = 1.170-1.812) and high and rising trajectories (HR = 1.244, 95%CI = 1.016-1.522) increased the risk. High multimorbidity trajectories (HR = 1.305, 95%CI = 1.094-1.556) and highest multimorbidity trajectories (HR = 1.393, 95%CI = 1.131-1.715) increased the risk.
conclusionThe results suggest that tracking trajectories of depressive symptoms, physical activity, and multiple disease states may be a potential and feasible screening method for identifying those at risk for RA.
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