Evidence map›Paper›PMID 40133919›Full record

ArticleBMC oral health2025

Laboratory investigation of the association between oral lichen planus and Hashimoto's thyroiditis.

Yang Liu, Yunju Tang, Zengtong Zhou, Xuemin Shen, Wei Liu

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Article in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yang LiuDepartment of Stomatology, Wuxi Medical Center, The Affiliated Wuxi People'S Hospital of Nanjing Medical University, Nanjing Medical University, Wuxi People'S Hospital, Wuxi, Jiangsu, China. liuyang2004@hotmail.com.
Yunju TangDepartment of Oral Mucosal Diseases, Shanghai Ninth People'S Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zengtong ZhouDepartment of Oral Mucosal Diseases, Shanghai Ninth People'S Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuemin ShenDepartment of Oral Mucosal Diseases, Shanghai Ninth People'S Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei LiuCollege of Stomatology, National Center for Stomatology, Shanghai Jiao Tong University, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China. liuweb@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies have shown some relationship between oral lichen planus (OLP) and certain systemic comorbidities. The aim of this study was to investigate laboratory parameters between cases of Hashimoto's thyroiditis (HT) concomitant with OLP and cases of HT only.

methodsThis case-control study comprised 59 HT patients with OLP and 76 without OLP, all of whom had 5 serum thyroid-related indicators, including thyroid peroxidase antibody (TPOAb), thyroglobulin antibody (TGAb), thyroid stimulating hormone (TSH), free triiodothyronine (FT3), and free thyroxine (FT4).

resultsCompared to cases of HT only, female predominance, presence of thyroid nodules, positive TGAb, and higher FT3/FT4 ratio were mainly observed in cases of HT concomitant with OLP (all P < 0.05). Multivariate regression analysis revealed that presence of thyroid nodules (odds ratio [OR], 10.328; 95% confidence interval [CI], 2.564-41.604), positive TGAb (OR, 6.936; 95%CI, 2.024-23.765), and higher FT3/FT4 ratio (OR, 2.577; 95%CI, 1.377-4.823) were associated significantly (all P < 0.005) with higher risk of OLP occurrence in 135 HT patients. Notably, these significant associations were not found among 30 male patients but did among 105 female patients in regression analysis.

conclusionThis retrospective study revealed that presence of thyroid nodule, positive TGAb, and high FT3/FT4 ratio as risk factors were significantly associated with OLP occurrence risk in female patients with HT. This suggests that female patients suffering from HT, particularly who presented with the risk factors, should be informed about the risk of OLP development and the need for oral mucosal examination to screen for lichen lesions.

Indexed as

Hashimoto DiseaseLichen Planus, OralAdultAgedAutoantibodiesCase-Control StudiesFemaleHumansIodide PeroxidaseMaleMiddle AgedSex FactorsThyroglobulinThyroid NoduleThyrotropinThyroxineanti-thyroglobulinanti-thyroid autoantibodiesAutoantibodiesIodide PeroxidaseThyroglobulinThyrotropinThyroxineTriiodothyronineFemale patientsHashimoto's thyroiditisOral lichen planusThyroid autoantibodiesThyroid nodule

Identifiers

PMID40133919
PMCPMC11934608

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