Evidence map›Paper›PMID 40133898›Full record

ArticleBMC pediatrics2025

Hemorrhagic cystitis in pediatric severe aplastic anemia undergoing haploidentical hematopoietic stem cell transplantation: incidence, risk factors and outcomes.

Kai Cui, Senlin Zhang, Mingchu Liang, ChenChen He, Jie Chen, Yufeng Wei, Shaoyan Hu, Jie Li

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Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

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8 authors.

Kai Cui *Department of Hematology and Oncology, Children'S Hospital of Soochow University, No. 92, Zhongnan Street, Suzhou, 215000, China.
Senlin Zhang *Department of Hematology and Oncology, Children'S Hospital of Soochow University, No. 92, Zhongnan Street, Suzhou, 215000, China.
Mingchu LiangDepartment of Nephrology and Immunology, Children'S Hospital of Soochow University, No. 92, Zhongnan Street, Suzhou, 215000, China.
ChenChen HeDepartment of Hematology and Oncology, Children'S Hospital of Soochow University, No. 92, Zhongnan Street, Suzhou, 215000, China.
Jie ChenDepartment of Hematology and Oncology, Children'S Hospital of Soochow University, No. 92, Zhongnan Street, Suzhou, 215000, China.
Yufeng WeiDepartment of Hematology and Oncology, Children'S Hospital of Soochow University, No. 92, Zhongnan Street, Suzhou, 215000, China.
Shaoyan HuDepartment of Hematology and Oncology, Children'S Hospital of Soochow University, No. 92, Zhongnan Street, Suzhou, 215000, China. hushaoyan@suda.edu.cn.
Jie LiDepartment of Hematology and Oncology, Children'S Hospital of Soochow University, No. 92, Zhongnan Street, Suzhou, 215000, China. lijiexy12345ab@aliyun.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHemorrhagic cystitis (HC) is a common complication of hematopoietic stem cell transplantation (HSCT) and may adversely affect the prognosis of patients. However, the risk factors associated with HC and its influence on prognosis remain unclear in pediatric Severe aplastic anemia (SAA) patients who underwent haploidentical HSCT (haplo-HSCT).

methodsClinical data from 116 SAA patients who received haplo-HSCT based on the 'Beijing Protocol' at the Children's Hospital of Soochow University between 2018 and 2023 were examined retrospectively. Potential risk factors were identified by univariate and multivariate logistic regression, and the effect of HC on overall survival (OS) was analyzed by Kaplan-Meier curves and log-rank tests.

results32 out of 116 patients (27.6%) developed HC and the median time to onset of HC was 12 days (range: 1-157 days) after HSCT. In multivariate analysis, Very SAA (VSAA) (OR = 3.47, 95% CI: 1.15-10.44), II-IV acute graft versus host disease (aGVHD) (OR = 2.75, 95% CI: 1.05-7.18) and pre-transplant iron overload (OR = 3.90, 95% CI: 1.27-11.94) were regarded as risk factors. Compared to the non-HC group and mild HC group, the severe HC group had the worst 2-year OS rates (non-HC: 94.0% ± 2.6%; mild HC: 96.0% ± 3.9%; severe HC: 71.4% ± 1.7%, P = 0.047).

conclusionFor pediatric SAA patients, VSAA, II-IV aGVHD, and pre-transplant iron overload elevate the risk of HC following haplo-HSCT. The development of severe HC can affect the clinical outcomes of patients.

Indexed as

Anemia, AplasticCystitisHematopoietic Stem Cell TransplantationHemorrhageTransplantation, HaploidenticalAdolescentChildChild, PreschoolCystitis, HemorrhagicFemaleGraft vs Host DiseaseHumansIncidenceInfantMalePrognosisChildrenHaploidentical hematopoietic stem cell transplantationHemorrhagic cystitisRisk factorsSevere aplastic anemia

Identifiers

PMID40133898
PMCPMC11938558

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.