Evidence map›Paper›PMID 40133893›Full record

ArticleDiagnostic pathology2025

A case of quadruple wild-type gastrointestinal stromal tumor with CDC42BPB::NTRK3 fusion and abundant lymphoid infiltration.

Wentao Xiang, Wei Yuan, Lei Ren, Wen Huang, Huaiyu Liang, Jie Huang, Lijuan Luan, Chen Xu, Yingyong Hou

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PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostic pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wentao XiangDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Wei YuanDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Lei RenDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Wen HuangDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Huaiyu LiangDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Jie HuangDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Lijuan LuanDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Chen XuDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Yingyong HouDepartment of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. hou.yingyong@zs-hospital.sh.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. The most common mutations in GISTs are those in receptor tyrosine kinase (KIT) and platelet-derived growth factor receptor alpha (PDGFRA). GISTs without KIT or PDGFRA mutations are defined as wild-type (WT) GISTs. The molecular changes, prognosis, and treatments of WT GISTs remain uncertain. Among WT GISTs, neurotrophic tyrosine receptor kinase (NTRK) fusions have rarely been reported. We report a case of quadruple wild-type GIST harboring a novel CDC42BPB::NTRK3 fusion. In this study, we described a 66-year-old male patient with intrajejunal lesion. This case showed massive lymphocytic and plasma cell infiltration, which caused diagnostic difficulties in morphology. CDC42BPB::NTRK3 fusion was detected via next-generation sequencing (NGS), and this finding was confirmed by fluorescence in situ hybridization (FISH), which revealed NTRK3 breakage. However, the expression of the Trk protein in tumor tissue was not detected by immunohistochemistry (IHC). This finding expands the genetic spectrum of NTRK rearrangements in GISTs.

Indexed as

Biomarkers, TumorGastrointestinal NeoplasmsGastrointestinal Stromal TumorsReceptor, trkCAgedHumansIn Situ Hybridization, FluorescenceMaleOncogene Proteins, FusionBiomarkers, TumorNTRK3 protein, humanOncogene Proteins, FusionReceptor, trkCGastrointestinal stromal tumorLymphoid infiltrationNTRK

Identifiers

PMID40133893
PMCPMC11934696

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.