SynthesisBMC veterinary research2025
Association between sperm DNA fragmentation and fertility parameters in farm animals: a systematic review and meta-analysis.
Synthesis in BMC veterinary research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Sperm DNA fragmentation and its influence on mammalian reproduction.Nature reviews. Urology · 2026Review
- Comprehensive Statistical Assessment of Post-Thaw Semen Quality in Two Conserved Norwegian Rooster Lines.Animals : an open access journal from MDPI · 2026Article
- Effects of Selenium Nanoparticles and Sodium Selenite Supplementation on Cryopreserved Ram Sperm Quality, Oxidative Status, and PRDX5 Gene Expression.Animals : an open access journal from MDPI · 2026Article
- Age-Associated Alterations in Sperm Quality and DNA Integrity in Cryopreserved Bali Bulls (Veterinary medicine international · 2026Article
- High Concentrations of Non-Esterified Fatty Acids During BovineJournal of developmental biology · 2025Article
- Effect of Centrifugation of Stallion Semen Through a Low Density Colloid Prior to Freezing on Sperm Cryosurvival.Animals : an open access journal from MDPI · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundAccurately predicting male fertility is crucial for the animal breeding industry due to its significant economic implications. Existing literature suggests that mammalian fertility is partially dependent on sperm DNA integrity. However, routine semen analysis often fails to detect DNA damage and does not consistently correlate with field fertility outcomes. While assessing sperm DNA integrity provides valuable biological insights, its role in diagnosing animal infertility remains uncertain.
resultsThis meta-analysis evaluated the association between sperm DNA fragmentation (SDF) and fertility in farm animals. Comprehensive searches were conducted using PubMed, Google Scholar, and Springer Link Library, with results stratified by animal species and SDF detection methods. Across 30 studies, the overall correlation coefficient (COR) between SDF and male fertility was -0.46 (95% confidence interval [CI]: -0.54 to -0.37; Z = -8.97; p < 0.001). A significant association was observed in bulls (COR = -0.47; 95% CI: -0.54 to -0.40; Z = -11.13; p < 0.001) and stallions (COR = -0.54; 95% CI: -0.72 to -0.29; Z = -3.83; p < 0.001), whereas no significant relationship was found in boars (COR = -0.19; 95% CI: -0.37 to 0.01; Z = -1.84; p = 0.07). The effect of SDF on male fertility was analyzed in 15 studies, demonstrating significantly higher SDF values in low-fertility animals compared to high-fertility groups (SMD = 0.85; 95% CI: 0.68 to 1.01; Z = 10.07; p < 0.001). This pattern was observed in both bulls (SMD = 1.21; 95% CI: 0.85 to 1.57; Z = 6.59; p < 0.001) and stallions (SMD = 0.64; 95% CI: 0.44 to 0.85; Z = 6.14; p < 0.001) subgroups.
conclusionsThese findings suggest that incorporating SDF assays into breeding soundness evaluations could enhance the accuracy of selecting high-quality breeding males for artificial breeding programs. However, further research with adequately powered studies, standardized methodologies, and appropriate sample sizes is necessary to fully elucidate the impact of elevated SDF on fertility in farm animals.
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