Evidence map›Paper›PMID 40133857›Full record

Trial reportBMC psychiatry2025

Treatment expectancy and credibility as predictors of concentrated exposure treatment outcomes in patients with difficult-to-treat obsessive-compulsive disorder.

Håvard Berg, Kristian Tjelle, Bjarne Hansen, Stian Solem, Thröstur Björgvinsson, Gerd Kvale, Kristen Hagen

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02656342 (Translational Approach to the Understanding and Treatment of Obsessive-Compulsive Disorder), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02656342 phase4completednot on this map

Translational Approach to the Understanding and Treatment of Obsessive-Compulsive Disorder (OCD). Can D-Cycloserine Enhance and Stabilize the Treatment-response in Relapsed and Non-responding OCD-patients? A Randomized, Double-blind, Placebo-controlled National Study

TypeinterventionalSponsorHaukeland University HospitalRan2015 to 2019Enrolled163ConditionsObsessive-Compulsive DisorderArmsD-Cycloserine, Placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Håvard BergDepartment of Psychiatry, Møre and Romsdal Hospital Trust, Molde, Norway.
Kristian TjelleDepartment of Psychiatry, Møre and Romsdal Hospital Trust, Molde, Norway.
Bjarne HansenBergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.
Stian SolemDepartment of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.
Thröstur BjörgvinssonDepartment of Psychiatry, Harvard Medical School, Boston, USA.
Gerd KvaleBergen Center for Brain Plasticity, Haukeland University Hospital, Bergen, Norway.
Kristen HagenDepartment of Psychiatry, Møre and Romsdal Hospital Trust, Molde, Norway. kristen.hagen@helse-mr.no.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTreatment readiness factors, such as treatment credibility and expectancy, are postulated to be predictors of outcomes within the context of cognitive behavioral therapy (CBT). Concentrated exposure therapy (cET) is a form of short-term, intensive, exposure-based CBT that has shown promising results. This study investigated whether treatment expectancy and credibility predict cET treatment outcomes in patients with difficult-to-treat (nonresponders and patients with relapse following CBT) obsessive-compulsive disorder (OCD).

methodsA total of 163 patients underwent 4 days of cET treatment. Treatment credibility and expectancy were measured using the Credibility/Expectancy Questionnaire (CEQ) prior to the start of treatment. OCD symptom severity was measured using the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) at pretreatment, posttreatment, 3-month follow-up, and 1-year follow-up. Work- and social functioning were measured before treatment and at the 1-year follow-up.

resultsHigher CEQ scores were significantly associated with lower Y-BOCS score at posttreatment and follow-up after controlling for age, sex, and pretreatment OCD, anxiety, and depression levels. The CEQ scores were also significantly associated with work- and social functioning at the 1-year follow-up. A receiver operating characteristic analysis suggested a mean item cutoff point of 92.5 (0-100 scale) for the CEQ, and 87% of the patients classified as having high expectancy had a positive treatment response.

conclusionsThis study confirmed that treatment expectancy and credibility are predictors of cET outcomes in patients with OCD. Higher scores on the CEQ were linked to better treatment results, both immediately and up to one year later. These insights highlight the need to consider patients' attitudes toward treatment in the early treatment phase.

trial registrationClinicalTrials.gov identifier: NCT02656342 (First registered: 2015-11-30).

Indexed as

Implosive TherapyObsessive-Compulsive DisorderAdultCognitive Behavioral TherapyFemaleHumansMaleMiddle AgedSeverity of Illness IndexSurveys and QuestionnairesTreatment OutcomeYoung AdultB4DTcETDifficult-to-treatOCDTreatment credibilityTreatment expectancy

Identifiers

PMID40133857
PMCPMC11938650

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.