Evidence map›Paper›PMID 40133829›Full record

ArticleBMC infectious diseases2025

The added value of diagnostics to characterize age-specific patterns of respiratory viral infections and coinfections and to detect emerging threats.

Alessandra Pierangeli, Ombretta Turriziani, Matteo Fracella, Roberta Campagna, Federica Frasca, Alessandra D'Auria, Carolina Scagnolari, Piergiorgio Roberto, Lilia Cinti, Gabriella D'Ettorre and 6 more

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Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Alessandra PierangeliMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina, 28, Rome, 00185, Italy. alessandra.pierangeli@uniroma1.it.ORCID http://orcid.org/0000-0003-0633-360X
Ombretta TurrizianiMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina, 28, Rome, 00185, Italy.
Matteo FracellaMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina, 28, Rome, 00185, Italy.
Roberta CampagnaMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina, 28, Rome, 00185, Italy.
Federica FrascaMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina, 28, Rome, 00185, Italy.
Alessandra D'AuriaMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina, 28, Rome, 00185, Italy.
Carolina ScagnolariMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina, 28, Rome, 00185, Italy.
Piergiorgio RobertoMicrobiology and Virology Unit, Policlinico Umberto I Hospital, Sapienza University, Rome, Italy.
Lilia CintiMicrobiology and Virology Unit, Policlinico Umberto I Hospital, Sapienza University, Rome, Italy.
Gabriella D'EttorreDepartment of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
Giancarlo CeccarelliDepartment of Public Health and Infectious Diseases, Sapienza University, Rome, Italy.
Laura PetrarcaDepartment of Pediatrics and Infantile Neuropsychiatry, Sapienza University, Rome, Italy.
Raffaella NennaDepartment of Pediatrics and Infantile Neuropsychiatry, Sapienza University, Rome, Italy.
Fabio MidullaDepartment of Pediatrics and Infantile Neuropsychiatry, Sapienza University, Rome, Italy.
Gioacchino GalardoMedical Emergency Unit, Policlinico Umberto I, Sapienza University, Rome, Italy.
Guido AntonelliMicrobiology and Virology Laboratory, Department of Molecular Medicine, Sapienza University, V.le Porta Tiburtina, 28, Rome, 00185, Italy.

Funding

European Union NextGeneration EU-MUR PNRR PE00000007, INF-ACT
6 · The paper itself

Abstract

backgroundPandemic restrictions caused variation in respiratory virus circulation until the winter of 2022/23. The aim of this study was to monitor respiratory virus cases in the 2023/24 epidemic season.

methodsChildren and adults attending Sapienza University Hospital for acute respiratory infections (October 2023-June 2024) were tested for respiratory viruses via molecular methods.

resultsOf the 1121 patients included, 880 (78%) were positive for rhinovirus (HRV, 32%), Influenza A (IAV, 29%), and respiratory syncytial virus (RSV, 28%). RSV is more common in infants, and IAV is more common in adults, whereas HRV is more common in children aged 1-5 years. IAV, RSV and HRV cocirculate in winter; HRV cases also occur in spring, along with Influenza B (IBV) and other viruses. Despite circulating in the same weeks, the number of observed coinfections was much lower than that predicted for IAV and RSV (p <.0001) and lower also for the IAV/IBV, IBV/RSV and RSV/HRV pairs (p <.0001, p =.0059, p =.015, respectively). IAV and RSV cocirculated with different patterns in different age groups. In fact, in children aged 1-5 years, the RSV peak preceded that of IAV, whereas in older age groups, the RSV peak occurred toward the end of IAV circulation. Sequencing of HRV/EV cases in spring revealed 25 HRV genotypes and two EV-C105 cases.

conclusionsRespiratory viruses can cause age-specific seasonal peaks that are modulated by viral interference phenomena. Molecular diagnostic data should be integrated with surveillance programs to characterize seasonal circulation patterns of common respiratory viruses and to rapidly detect the next pandemic threat.

Indexed as

CoinfectionRespiratory Tract InfectionsVirus DiseasesAdolescentAdultAgedAge FactorsChildChild, PreschoolFemaleHumansInfantInfant, NewbornInfluenza A virusInfluenza, HumanItalyEnterovirus-C105Molecular epidemiologyRespiratory virus diagnosticsViral coinfectionsViral interference

Identifiers

PMID40133829
PMCPMC11934565

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.