Evidence map›Paper›PMID 40133795›Full record

Trial reportBMC anesthesiology2025

Efficacy of adding dexmedetomidine as adjuvant with bupivacaine in ultrasound-guided intermediate cervical plexus block for thyroidectomy surgery: randomized controlled study.

Mamdouh Mahmoud Mostafa, Reham M Gamal, Aya M Ahmed Baiomy, Mohamed Elsayed Hassan, Jehan Mohamed Kamal, Thabet Ts, Tamer A Kotb, Mai M Elrawas

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC anesthesiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07547124 (Association Between Postoperative Analgesic Approaches and Quality of Recovery and Swallowing Pain in Patients Undergoing Elective Total Thyroidectomy), which is not on this map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07547124 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Association Between Postoperative Analgesic Approaches and Quality of Recovery and Swallowing Pain in Patients Undergoing Elective Total Thyroidectomy: A Prospective Observational Study

TypeobservationalSponsorIstinye UniversityRan2026 to 2026Enrolled100ConditionsPostoperative PainArmsCervical Plexus Block
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Effect of Bilateral Superficial Cervical Plexus Block on Postoperative Pain in Thyroid and Parathyroid Surgery: A Systemic Review and Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mamdouh Mahmoud MostafaDepartment of Anesthesia, SICU and pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Reham M GamalDepartment of Anesthesia, SICU and pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Aya M Ahmed BaiomyDepartment of Anesthesia, SICU and pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Mohamed Elsayed HassanDepartment of Anesthesia, SICU and pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Jehan Mohamed KamalDepartment of Anesthesia, SICU and pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Thabet TsDepartment of Anesthesia, SICU and pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Tamer A KotbDepartment of Anesthesia, SICU and pain Management, National Cancer Institute, Cairo University, Cairo, Egypt.
Mai M ElrawasDepartment of Anesthesia, SICU and pain Management, National Cancer Institute, Cairo University, Cairo, Egypt. mai.elrawas@nci.cu.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOne important aspect of a successful thyroidectomy recovery is the level of pain postoperatively. This research aimed to determine the effectiveness of an ultrasound-guided intermediate cervical plexus block (CPB) for thyroidectomy with dexmedetomidine added as an adjuvant to bupivacaine. The primary outcome was the duration of analgesia defined as the time till the first request for rescue analgesia. The secondary outcomes were the total amount of fentanyl consumed intraoperatively, total patient's opioids requirements within 24 h postoperative, VAS, and complications.

methodsThis randomized controlled double-blinded study included 60 patients aged 18 to 60 years, all of whom underwent thyroidectomy for thyroid cancer. Patients were randomly allocated into two equal groups, the B Group (n = 30) received bilateral intermediate CPB, with 20 ml bupivacaine 0.25%, and the DB Group (n = 30) received bilateral intermediate CPB with 20 ml of bupivacaine 0.25% plus 1 µg/kg dexmedetomidine.

resultsThe DB Group showed a significantly longer duration of analgesia (p < 0.001), significantly less total intraoperative fentanyl consumption (p = 0.005), and significantly less total postoperative morphine consumption (p < 0.001). Also, postoperative pain scores, heart rate, and mean arterial pressure were significantly lower in the DB group than in the B Group and sometimes points.

conclusionsThe addition of dexmedetomidine to bupivacaine in ultrasound-guided intermediate CPB for thyroidectomy significantly prolonged analgesia and reduced postoperative opioid consumption.

Indexed as

Anesthetics, LocalBupivacaineCervical Plexus BlockDexmedetomidinePostoperative PainThyroidectomyUltrasonography, InterventionalAdolescentAdultAnalgesics, Non-NarcoticAnalgesics, OpioidDouble-Blind MethodFemaleFentanylHumansMaleAnalgesics, Non-NarcoticAnalgesics, OpioidAnesthetics, LocalBupivacaineDexmedetomidineFentanylBupivacaineDexmedetomidineEfficacyIntermediate cervical plexus block

Identifiers

PMID40133795
PMCPMC11934596

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.