ArticleMedical physics2025
Comparative analysis of auger electron emission libraries and Monte Carlo track structure codes for DNA-targeted auger electron therapy.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Contemporary opportunities and potential of Auger electron-emitting theranostics.Theranostics · 2026Review
- Monte Carlo-based subcellular comparison of electron energy deposition byEJNMMI physics · 2025Article
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5 authors.
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Abstract
backgroundOver the past decade, theranostic radiopharmaceuticals have gained significant attention, driven by the clinical success of agents like [ PURPOSE: This study aims to evaluate and compare two well-recognized data libraries to obtain the Auger electron energy spectra and three Monte Carlo (MC) track codes to analyze DNA-scale energy deposition from Auger electrons emitted by
methodsAn in-house MC code was developed in MATLAB to obtain Auger electron energy spectra using the McGuire and Evaluated Atomic Data Library (EADL) datasets. A MC study using Geant4 utilized these spectra to analyze DNA dsb yields, applying a 17.5 eV threshold to define strand breaks. Subsequently, a sensitivity analysis compared energy deposition and dsb yields across MC track codes - Geant4, PHITS, and MCNP6.2 - assessing their effectiveness in modeling DNA damage from Auger emitters and bench-marking these findings against literature data using Moca7B.
resultsThe study found that the average dsb yields for the
conclusionsThe EADL library produces more electrons than McGuire, but this does not affect the amount of local DNA damage significantly, as most of the additional electrons fall below the 17.5 eV damage threshold. Both libraries yield similar DNA damage outcomes. In addition, our analysis highlights the need for specific energy thresholds in MC codes to ensure accurate DNA damage predictions in Auger electron studies.
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