SynthesisArchives of orthopaedic and trauma surgery2025
Mechanical versus kinematic alignment for total knee arthroplasty: a meta-analysis.
Synthesis in Archives of orthopaedic and trauma surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Alignment strategy does not confer clinically meaningful advantages in medial pivot total knee arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2026Pooled it
- Posterior cruciate ligament management in medial pivot total knee arthroplasty: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2026Pooled it
- Robotic-assisted versus conventional total knee arthroplasty for treating osteoarthritis.The Cochrane database of systematic reviews · 2026Pooled it
- Coronal plane alignment of the knee (CPAK) phenotypes and their relationship with gap patterns in robotic-assisted total knee arthroplasty: a clinical trial.Orthopadie (Heidelberg, Germany) · 2026Trial
- Improved accuracy of functional alignment restoration with robotic-assisted total knee arthroplasty : A quasi-randomized controlled trial.Orthopadie (Heidelberg, Germany) · 2026Trial
- Perioperative comparison between robotic-assisted and freehand total knee arthroplasty : A quasi-randomized controlled trial.Orthopadie (Heidelberg, Germany) · 2026Trial
- Patellar resurfacing in primary total knee arthroplasty is associated with fewer reoperations but comparable clinical and functional outcomes: an umbrella review of meta-analyses.Arthroplasty (London, England) · 2026Review
- In Vitro Wear Simulation of a Kinematically Aligned Knee Implant Tilted at an Angle of 8°.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- Bridging postural biomechanics and knee arthroplasty success.Arthroplasty (London, England) · 2026Review
- Unrestricted kinematic alignment for total knee arthroplasty : a mid- to long-term follow-up non-designer single surgeon study with survival analysis.Bone & joint open · 2026Article
- Deep Learning-Based Full-Process Automatic CPAK Classification System and Its Application in the Analysis of Alignment Outcomes Before and After Knee Arthroplasty.Diagnostics (Basel, Switzerland) · 2026Article
- Learning curve for robotic-assisted total knee arthroplasty.Journal of orthopaedic surgery and research · 2026Article
- Robotic-assisted total knee replacement: a narrative review of evolution, clinical impact, and future prospects in AI-driven precision surgery.Annals of medicine and surgery (2012) · 2026Review
- Does robotic assistance influence the length of stay after total knee arthroplasty?Journal of robotic surgery · 2026Article
- Alternative alignment clinical study: study protocol for a prospective, randomised, controlled study of the outcomes and cost effectiveness of triathlon CR knee replacement system: traditional philosophy versus alternative alignment philosophy.Journal of orthopaedic surgery and research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe present meta-analysis compared mechanical versus kinematic alignment in total knee arthroplasty (TKA). The outcomes of interest were patient-reported outcome measures (PROMs), range of motion (ROM), and revision rate.
methodsThis study was conducted according to the 2020 PRISMA statement. In July 2024, PubMed, Web of Science, Google Scholar, and Embase were accessed without time constraints. All the clinical studies that compared mechanical versus kinematic alignment in total knee arthroplasty were accessed.
results30 studies (3133 TKAs) were collected. The mean duration of the follow-up was 30.8 ± 38 months. No difference was found in Knee KSS-F, Knee Society Score (KSS, P = 0.2) and its function subscale (P = 0.3), visual analogue scale (VAS, P = 0.3), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC, P = 0.2), Oxford Knee Score (OKS, P = 0.5). No difference was found in the rate of revision (P = 0.4). The ROM was slightly greater in the kinematic group (P < 0.0001).
conclusionPROMs and revision did not show a difference between mechanical and kinematic alignment in TKA. However, a minimal difference in the ROM was evidenced, which probably does not have clinical relevance. LEVEL OF EVIDENCE: Level IV, systematic review and meta-analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.