Evidence map›Paper›PMID 40133697›Full record

ArticleNPJ precision oncology2025

Real-world experience of Molecular Tumour Boards for clinical decision-making for cancer patients.

Julio Herrero Colomina, Eleanor Johnston, Kate Duffus, Zoulikha M Zaïr, Fiona Thistlethwaite, Matthew Krebs, Louise Carter, Donna Graham, Natalie Cook

Abstract read
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Julio Herrero ColominaThe Christie NHS Foundation Trust, Manchester, UK.
Eleanor JohnstonThe Christie NHS Foundation Trust, Manchester, UK.
Kate DuffusThe Christie NHS Foundation Trust, Manchester, UK.
Zoulikha M ZaïrThe Christie NHS Foundation Trust, Manchester, UK.
Fiona ThistlethwaiteThe Christie NHS Foundation Trust, Manchester, UK.
Matthew KrebsThe Christie NHS Foundation Trust, Manchester, UK.
Louise CarterThe Christie NHS Foundation Trust, Manchester, UK.
Donna GrahamThe Christie NHS Foundation Trust, Manchester, UK.
Natalie CookThe Christie NHS Foundation Trust, Manchester, UK. natalie.cook17@nhs.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular Tumour Boards (MTBs) play a crucial role in interpreting genomic results and providing treatment recommendations. We investigated the real-world impact of MTBs on clinical decision-making by surveying health care professionals (HCPs) across the UK; 44 participants from 11 MTBs took part in the study. 97.7% of respondents felt that MTBs increased awareness of available clinical trials matched to genomic alterations, 84% reported more confidence in interpreting genomic data, and 95.4% valued MTBs as educational. Hurdles to the discussion at MTBs included frequency and capacity of MTBs (ctDNA), sample collection and laboratory turnaround time (Tissue samples). One-third of respondents encountered challenges attending MTBs regularly due to workload. The survey highlighted areas for optimisation, such as meeting efficiency, rapid molecular analysis turnaround time, reliable trial matching tools, and ensuring MTBs are included in HCP's job plans.

Identifiers

PMID40133697
PMCPMC11937402

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.