ArticleDiscover oncology2025
Albumin-bilirubin grade as an alternative to Child-Pugh class for evaluating liver function within staging systems for hepatocellular carcinoma.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic value of prognostic nutritional index in patients with hepatocellular carcinoma undergoing hepatectomy: a systematic review and meta-analysis.Frontiers in oncology · 2026Pooled it
- Risk factors for catheter-related complications after ultrasound-guided percutaneous transhepatic biliary drainage in malignant obstructive jaundice.BMC surgery · 2026Article
- The prognostic value of selected indices combination in hepatocellular carcinoma patients treated with sorafenib.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2026Article
- Albumin-bilirubin score as a practical tool for prognostication in metabolic-associated steatotic liver disease.World journal of hepatology · 2025Article
- Review
- Association between albumin-bilirubin score and sarcopenia in middle-aged Americans: a cross-sectional study.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundMultiple staging systems for hepatocellular carcinoma (HCC) have been proposed, where Child-Pugh class (CP) is utilized to assess liver function. However, several inherent limitations occur in CP. We investigated whether replacement of CP by model for end-stage liver disease grade (MELD) or albumin-bilirubin grade (ALBI) in currently used HCC staging systems could achieve better prediction performance.
methods568 patients first diagnosed with HCC were retrospectively analyzed. We compared each original and modified systems by calculating their Harrell's concordance index (C-index), Wald χ
resultsThe study identified severity of liver dysfunction, malignancy of tumor, and health status of patients as crucial factors of prognosis in HCC. In the entire cohort, replacement of CP by ALBI in staging systems resulted in comparable or even improved prediction performance for HCC prognosis, with higher C-index, higher Wald χ
conclusionOur study confirms comparable or, in some cases, superior prognostic performance of the ALBI grade to the CP class across specific HCC staging systems. ALBI may serve as a complementary or alternative measure that may enhance prognostic accuracy, conducive to therapeutic decisions of oncologists and to the effective management of HCC patients.
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