Evidence map›Paper›PMID 40133611›Full record

ArticleNPJ precision oncology2025

Copy-number alterations in cell-free DNA can be transient or harbingers of clonal hematopoiesis.

Stefania Tuveri, Nathalie Brison, Tatjana Jatsenko, Barbara Dewaele, Cindy Melotte, Charlotte Maggen, Vincent Vandecaveye, Peter Vandenberghe, Frederic Amant, Liesbeth Lenaerts and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Stefania TuveriLaboratory for Cytogenetics and Genome Research, Department of Human Genetics, KU Leuven, Leuven, Belgium.
Nathalie BrisonLaboratory for Cytogenetics and Genome Research, Department of Human Genetics, KU Leuven, Leuven, Belgium.
Tatjana JatsenkoLaboratory for Cytogenetics and Genome Research, Department of Human Genetics, KU Leuven, Leuven, Belgium.
Barbara DewaeleLaboratory for Malignant Disorders, Department of Human Genetics, KU Leuven, Leuven, Belgium.
Cindy MelotteLaboratory for Cytogenetics and Genome Research, Department of Human Genetics, KU Leuven, Leuven, Belgium.
Charlotte MaggenDepartment of Oncology, University Hospitals Leuven, Leuven, Belgium.
Vincent VandecaveyeDepartment of Radiology, University Hospitals Leuven, Leuven, Belgium.
Peter VandenbergheLaboratory for Malignant Disorders, Department of Human Genetics, KU Leuven, Leuven, Belgium.
Frederic AmantGynaecological Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
Liesbeth Lenaerts *Gynaecological Oncology, Department of Oncology, KU Leuven, Leuven, Belgium.
Joris R Vermeesch *Laboratory for Cytogenetics and Genome Research, Department of Human Genetics, KU Leuven, Leuven, Belgium. joris.vermeesch@kuleuven.be.

Funding

Fonds Wetenschappelijk Onderzoek 1S74420NFonds Wetenschappelijk Onderzoek S003422NKom Op Tegen Kanker KUL/2018/11468/1KU Leuven C14/22/125
6 · The paper itself

Abstract

Genome-wide plasma cfDNA pan-cancer screening of 1002 healthy elderly identified 15 individuals with CNAs of unknown origin. Nine participants were reassessed over 3-5 years through health questionnaires, WB-MRI, and cfDNA and blood analyses. CNAs resolved in two cases but persisted in seven mainly associated with low-grade clonal mosaicism. These findings suggest cfDNA CNAs may be transient or serve as early markers of clonal mosaicism, preceding clinical detection by years.

Identifiers

PMID40133611
PMCPMC11937393

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.