ArticleNature medicine2025
Prospective, multicenter validation of a platform for rapid molecular profiling of central nervous system tumors.
Abstract readMulticenter StudyValidation Study
In one paragraph
Article in Nature medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed.
- Multidisciplinary recommendations for routine follow-up of isocitrate dehydrogenase‑mutant glioma in 2026: Adapting clinical practice to the molecular era.Neuro-oncology practice · 2026Review
- Epigenetic Alterations in Meningiomas-A Review.Biomedicines · 2026Review
- From Anatomy to Outcome: Linking Glioma Location Patterns to Survival Using Non-Negative Matrix Factorization.Clinical neuroradiology · 2026Article
- DNA Methylation Profiling in IDH-Mutant Gliomas: Biological Evolution, Molecular Grading and Clinical Implementation.Neuropathology and applied neurobiology · 2026Review
- Surgical resection in medulloblastoma: a crossroads in the molecular era.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- The emerging role of intraoperative nanopore sequencing on the neurosurgical strategy in paediatric embryonal brain tumours.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Multidisciplinary management of meningiomas in the era of precision oncology.Nature reviews. Clinical oncology · 2026Review
- Long-read sequencing technologies and bioinformatics: a new perspective for decoding DNA methylation modifications.Journal of translational medicine · 2026Review
- Hetairos is a histology-based artificial intelligence model for predicting central nervous system tumor methylation subtypes.Nature cancer · 2026Article
- Neurosurgical Application of Artificial Intelligence in Pediatric Neuro-Oncology.Journal of Korean Neurosurgical Society · 2026Article
- Umi-pipeline-nf: a modular and scalable workflow for UMI-tagged nanopore amplicon analysis with real-time sequencing integration and GPU-acceleration.Bioinformatics (Oxford, England) · 2026Article
- Nanopore-targeted sequencing improves the diagnosis and treatment of patients with infectious ascites.Journal of translational medicine · 2026Article
- AI-Based Methods in Neuropathology for Diagnosis and Treatment of Brain Tumors.European journal of neurology · 2026Review
- MGMT promoter methylation modulates the effect of residual tumor on survival after re-resection of recurrent glioblastoma.Acta neuropathologica communications · 2026Article
- Article
- Neurooncology: 2026 update.Free neuropathology · 2026Review
- The utility of intraoperative magnetic resonance imaging in recurrent glioblastoma surgery: A volumetric analysis.Brain & spine · 2026Article
- The transformative impact of ultra-rapid nanopore sequencing in precision medicine.Frontiers in immunology · 2026Review
- AI-Powered Histology for Molecular Profiling in Brain Tumors: Toward Smart Diagnostics from Tissue.Cancers · 2025Review
- Disordered DNA methylation leads to targetable transcriptional plasticity in ATRT.Acta neuropathologica communications · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
59 authors.
Areeba PatelDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-0374-4227
Kirsten GöbelDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0009-0006-2117-6381
Sebastian IlleDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Felix HinzDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Natalie SchoebeDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Henri BogumilDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Jochen MeyerDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Michelle BrehmDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Helin KardoDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Daniel SchrimpfDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Artem LomakinDivision of Artificial Intelligence in Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Michael RitterDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Pauline GöllerDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Paul KerbsDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5525-1374
Lisa PfeiferDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0009-0009-5520-9438
Stefan HamelmannDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Christina BlumeDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Franziska M IppenDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Natalie BerghausDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.
Philipp EuskirchenDepartment of Neuropathology, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-9138-805X
Leonille SchweizerInstitute of Neurology (Edinger Institute), University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Claus HultschigInstitute for Pathology, Division of Neuropathology, University Hospital Basel, Basel, Switzerland.ORCID http://orcid.org/0009-0003-1178-8999
Nadine Van RoyCenter for Medical Genetics Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium.
Jo Van DorpeDepartment of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0001-8175-2930
Joni Van der MeulenCenter for Medical Genetics Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium.
Siebe LoontiensCenter for Medical Genetics Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium.ORCID http://orcid.org/0000-0002-4602-4580
Franceska DedeurwaerdereDepartment of Pathology, AZ Delta, Roeselare, Belgium.ORCID http://orcid.org/0000-0003-4608-1101
Henning LeskeVilhelm Magnus Laboratory, Department of Neurosurgery, Oslo University Hospital, Oslo, Norway.
Skarphéðinn HalldórssonVilhelm Magnus Laboratory, Department of Neurosurgery, Oslo University Hospital, Oslo, Norway.
Graeme FoxSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Simon DeaconSchool of Medicine, University of Nottingham, Nottingham, UK.
Inswasti CahyaniSchool of Life Sciences, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-1171-3255
Nadine HolmesSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Satrio WibowoSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Rory MunroSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Dan MartinSchool of Medicine, University of Nottingham, Nottingham, UK.
Abid SharifSchool of Medicine, University of Nottingham, Nottingham, UK.
Mark HousleySchool of Medicine, University of Nottingham, Nottingham, UK.
Robert GoldspringSchool of Medicine, University of Nottingham, Nottingham, UK.
Sebastian BrandnerDivision of Neuropathology, National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0002-9821-0342
Somak RoyCincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jürgen HenchInstitute for Pathology, Division of Neuropathology, University Hospital Basel, Basel, Switzerland.
Stephan FrankInstitute for Pathology, Division of Neuropathology, University Hospital Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0001-6165-0187
Andreas UnterbergDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
Violaine GoidtsBrain Tumor Translational Targets, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Natalie JägerHopp Children's Tumor Center (KiTZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-9589-7580
Simon PaineSchool of Medicine, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-1434-3931
Stuart SmithSchool of Medicine, University of Nottingham, Nottingham, UK.ORCID http://orcid.org/0000-0002-4556-2707
Christel Herold-MendeDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-1915-745X
Wolfgang WickDepartment of Neurology, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6171-634X
Stefan M PfisterHopp Children's Tumor Center (KiTZ), Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5447-5322
Einar O Vik-MoVilhelm Magnus Laboratory, Department of Neurosurgery, Oslo University Hospital, Oslo, Norway.ORCID http://orcid.org/0000-0001-8303-4123
Andreas von DeimlingDepartment of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5863-540X
Sandro KriegDepartment of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-4050-1531
David Tw JonesHopp Children's Tumor Center (KiTZ), Heidelberg, Germany.
Matthew LooseSchool of Life Sciences, University of Nottingham, Nottingham, UK.
Matthias SchlesnerBiomedical Informatics, Data Mining and Data Analytics, University of Augsburg, Augsburg, Germany.ORCID http://orcid.org/0000-0002-5896-4086
Martin Sill *Hopp Children's Tumor Center (KiTZ), Heidelberg, Germany. m.sill@kitz-heidelberg.de.ORCID http://orcid.org/0000-0001-7616-7665
Felix Sahm *Department of Neuropathology, University Hospital Heidelberg, Heidelberg, Germany. felix.sahm@med.uni-heidelberg.de.ORCID http://orcid.org/0000-0001-5441-1962
Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) CRC1389
Abstract
Molecular data integration plays a central role in central nervous system (CNS) tumor diagnostics but currently used assays pose limitations due to technical complexity, equipment and reagent costs, as well as lengthy turnaround times. We previously reported the development of Rapid-CNS
Indexed as
Central Nervous System NeoplasmsDNA MethylationFemaleHigh-Throughput Nucleotide SequencingHumansProspective Studies
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.