Evidence map›Paper›PMID 40133500›Full record

ArticleImmunologic research2025

Pivotal epitopes for islet antigen-specific CD8

Yang Chen, Min Shen, Yong Gu, Xinyu Xu, Lingling Bian, Fan Yang, Shuang Chen, Li Ji, Jin Liu, Jing Zhu and 14 more

Abstract read
PubMed Publisher
In one paragraph

Article in Immunologic research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Yang Chen *Department of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Min Shen *Department of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Yong GuDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Xinyu XuDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Lingling BianDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Fan YangDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Shuang ChenDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Li JiDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Jin LiuDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Jing ZhuDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Zheng ZhangDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Qi FuDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Yun CaiDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Heng ChenDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Kuanfeng XuDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Min SunDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Xuqin ZhengDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Jie ShenHLA Laboratory, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Hongwen ZhouDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Mei ZhangDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China.
Kathryn HaskinsDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
Liping YuBarbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 North Ursula Street, Aurora, CO, 80045, USA.
Tao YangDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China. yangt@njmu.edu.cn.
Yun ShiDepartment of Endocrinology & Metabolism, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, Jiangsu, China. drshiyun@163.com.

Funding

National Key Research and Development Program of China 2016YFC1305000National Natural Science Foundation of China 81700689, 81530026, 81900708, 82230028
6 · The paper itself

Abstract

A proportion of patients with new-onset diabetes share similar symptoms with type 1 diabetes (T1D) patients but they are negative for islet antigen-specific autoantibodies. This study was to develop an islet antigen-specific CD8

Indexed as

CD8-Positive T-LymphocytesDiabetes Mellitus, Type 1Epitopes, T-LymphocyteHLA-A2 AntigenIslets of LangerhansAdolescentAdultAllelesAutoantibodiesAutoantigensChildEnzyme-Linked Immunospot AssayFemaleHumansMaleMiddle AgedAutoantibodiesAutoantigensEpitopes, T-LymphocyteHLA-A*02:01 antigenHLA-A2 AntigenIslet antigen-specific T cellsIslet-specific autoantibodiesT cell epitopesType 1 diabetes

Identifiers

PMID40133500

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.