ArticleScientific reports2025
A Mendelian randomized study of circulating antioxidants in the diet and risk of cardiovascular disease.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- EAT-Lancet Diet, Plasma Metabolites, and Risk of Peripheral Artery Disease: A Prospective Cohort Study.Journal of the American Heart Association · 2026Article
- Dysregulated Redox Signaling and Its Impact on Inflammatory Pathways, Mitochondrial Dysfunction, Autophagy and Cardiovascular Diseases.Antioxidants (Basel, Switzerland) · 2025Review
- Dietary antioxidants and mortality in early-stage CKM syndrome: insights from NHANES.Nutrition & metabolism · 2025Article
- Diversity of Bioactive Compounds in Microalgae: Key Classes and Functional Applications.Marine drugs · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular diseases (CVD) are a major global mortality cause, heavily impacted by diet and oxidative stress. This study investigates the causal effects of five circulatory antioxidants on various cardiovascular diseases using Mendelian randomization (MR) to mitigate confounding biases.We conducted a two-sample Mendelian Randomization (MR) analysis utilizing summary-level genome-wide association study (GWAS) data from both the UK Biobank and FinnGen. Genetic instrumental variables for antioxidants, including vitamin A, beta-carotene, vitamin C, α-tocopherol, and lycopene, were identified based on rigorous criteria. The outcomes included arrhythmia, cardiomyopathy, heart failure, myocardial infarction, pericarditis, angina pectoris and coronary atherosclerosis.Higher genetically determined levels of α-tocopherol were associated with an increased risk of myocardial infarction (OR 5.10, 95% CI 2.92-8.91, P < 0.001) and cardiac arrhythmias (OR 1.94, 95% CI 1.34-2.83, P = 0.001). Retinol was linked to heightened risks of cardiomyopathy (OR 6.38, 95% CI 1.23-33.20, P = 0.028) and heart failure (OR 2.26, 95% CI 1.01-5.07, P = 0.047). A meta-analysis corroborated the pathogenic effects of α-carotene on arrhythmias (OR, 2.00; 95% CI, 1.39-2.86; P < 0.001) and myocardial infarction (OR, 4.81; 95% CI, 2.84-8.15; P < 0.001), α-tocopherol on angina pectoris (OR: 4.33; 95% CI: 2.07-9.09; P < 0.001) and coronary atherosclerosis (OR: 5.34; 95% CI: 2.81-10.12; P < 0.001).Our study indicates that elevated levels of specific antioxidants, particularly α-tocopherol and retinol, may increase the risk of certain cardiovascular diseases. Further research is necessary to clarify the impact of these antioxidants on cardiovascular health and to explore potential gene-environment interactions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.