ArticleScientific reports2025
Natural infection of Trypanosoma Cruzi in client-owned-dogs from rural Yucatan, Mexico.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic diversity and geographical distribution of Trypanosoma cruzi DTUs in Mexico: A Systematic Review.Revista da Sociedade Brasileira de Medicina Tropical · 2026Pooled it
- Article
- Epitope mapping of vaccine antigens Tc24 and TSA1 with antibodies from Trypanosoma cruzi-infected patients.Genes and immunity · 2026Article
- Randomized field trial of a therapeutic vaccine against Trypanosoma cruzi natural infection in dogs and correlates for efficacy.NPJ vaccines · 2025Article
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Authors and funding
12 authors.
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Abstract
Dogs play a crucial role in the transmission cycle of Trypanosoma cruzi and their presence in domicile increases the risk of infection in humans. In Yucatán, Mexico previous studies have reported T. cruzi infection in dogs from both rural and urban areas, which we expanded here, to better understand infection dynamics. A total of 186-dogs were screened for T. cruzi infection by PCR and serology. Parasite burden, genotype, immune response, cardiac alterations, and roaming behavior of the dogs were analyzed. The T. cruzi prevalence was 26.8% (50/186). Genotyping of T. cruzi revealed the predominance of TcI parasites, although most dogs (15/25, 60%) harbored mixed infections with additional DTUs including TcII, TcIV, TcV and TcVI. Antibodies against T. cruzi proteins were detected in > 90% of infected dogs, confirming their immunogenicity in natural infections. Mild ECG abnormalities were present in 40% of infected dogs. A logistic model suggested that the interplay between the host responses to multiple parasite strains could mediate differences in disease severity (P = 0.0002, R
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