ArticleScientific reports2025
A two sample Mendelian randomized study of the association of sex hormones and behavioral and clinical risk factors with macular hole.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bidirectional genetic and phenotypic links between smoking and striatal iron content involving dopaminergic and inflammatory pathways.Addiction (Abingdon, England) · 2026Article
- Toremifene-induced bilateral macular crystalline deposits with cystic cavitation: a case report.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Macular hole (MH) is a disease of the vitreoretinal interface that develops in relation to age and gender, and is 3.3 times more prevalent in females than in males. However, it remains inconclusive whether gender plays a role in the pathogenesis of MH. We adopted a two-sample Mendelian randomisation (MR) analysis to explore the relationship between free testosterone, bioavailable testosterone, oestradiol, menopause, smoking, alcohol consumption, type 2 diabetes, diastolic blood pressure, and systolic blood pressure and the risk of MH. We found that genetically predicted free testosterone levels in males were significantly associated with an increased risk of MH (IVW model: OR = 1.642; 95% CI, 1.162-2.322; P = 0.005), while genetically predicted oestradiol levels in females were significantly associated with a reduced risk of MH (IVW model: OR = 0.711; 95% CI, 0.517-0.978; P = 0.036). A sensitivity analysis verified the robustness of the causal relationship. MVMR results indicate that oestradiol in females is associated with MH risk using the IVW method (OR = 0.66; 95% CI, 0.47-0.88; P = 0.011). Our study demonstrates that the genetic risk of free testosterone in males and oestradiol in females may be correlated with MH risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.